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dc.contributor.authorKurenbach, B.en
dc.contributor.authorGibson, P. S.en
dc.contributor.authorHill, Amy Men
dc.contributor.authorBitzer, A. S.en
dc.contributor.authorSilby, M. W.en
dc.contributor.authorGodsoe, Williamen
dc.contributor.authorHeinemann, J. A.en
dc.date.accessioned2018-07-05T03:53:58Z
dc.date.available2017-11-17en
dc.date.issued2017-12-01en
dc.date.submitted2017-11-02en
dc.identifier.citationKurenbach et al. (2017). Herbicide ingredients change Salmonella enterica sv.Typhimurium and Escherichia coli antibiotic responses. Microbiology, 163(12), 1791-1801. doi:10.1099/mic.0.000573en
dc.identifier.issn1350-0872en
dc.identifier.urihttps://hdl.handle.net/10182/10051
dc.description.abstractHerbicides are frequently released into both rural and urban environments. Commercial herbicide formulations induce adaptive changes in the way bacteria respond to antibiotics. Salmonella enterica sv. Typhimurium and Escherichia coli were exposed to common co-formulants of formulations, and S. enterica sv. Typhimurium was exposed to active ingredients dicamba, 2,4-D and glyphosate to determine what ingredients of the commercial formulations caused this effect. Coformulants Tween80 and carboxymethyl cellulose induced changes in response, but the pattern of the responses differed from the active ingredients, and effect sizes were smaller. A commercial wetting agent did not affect antibiotic responses. Active ingredients induced changes in antibiotic responses similar to those caused by complete formulations. This occurred at or below recommended application concentrations. Targeted deletion of efflux pump genes largely neutralized the adaptive response in the cases of increased survival in antibiotics, indicating that the biochemistry of induced resistance was the same for formulations and specific ingredients. We found that glyphosate, dicamba, and 2,4-D, as well as co-formulants in commercial herbicides, induced a change in susceptibility of the potentially pathogenic bacteria E. coli and S. enterica to multiple antibiotics. This was measured using the efficiency of plating (EOP), the relative survival of the bacteria when exposed to herbicide and antibiotic, or just antibiotic, compared to survival on permissive media. This work will help to inform the use of non-medicinal chemical agents that induce changes in antibiotic responses.en
dc.format.extent1791-1801en
dc.language.isoenen
dc.publisherMicrobiology Societyen
dc.relationThe original publication is available from - Microbiology Society - https://doi.org/10.1099/mic.0.000573en
dc.relation.urihttps://doi.org/10.1099/mic.0.000573en
dc.rights©2017 The Authors. This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/, which permits unrestricted use, distribution and reproduction in any medium, provided the original author and source are credited.en
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en
dc.subjectpesticidesen
dc.subjectantibioticsen
dc.subjectantibiotic resistant bacteriaen
dc.subjectMicrobiologyen
dc.titleHerbicide ingredients change Salmonella enterica sv. Typhimurium and Escherichia coli antibiotic responsesen
dc.typeJournal Article
lu.contributor.unitLincoln Universityen
lu.contributor.unitBio-Protection Research Centreen
lu.contributor.unitResearch Management Officeen
lu.contributor.unit/LU/Research Management Office/2018 PBRF Staff groupen
dc.identifier.doi10.1099/mic.0.000573en
dc.subject.anzsrc0607 Plant Biologyen
dc.subject.anzsrc0602 Ecologyen
dc.subject.anzsrc0605 Microbiologyen
dc.subject.anzsrcMD Multidisciplinaryen
dc.relation.isPartOfMicrobiologyen
pubs.issue12en
pubs.organisational-group/LU
pubs.organisational-group/LU/BPRC
pubs.organisational-group/LU/Research Management Office
pubs.organisational-group/LU/Research Management Office/2018 PBRF Staff group
pubs.publication-statusPublisheden
pubs.volume163en
dc.identifier.eissn1465-2080en
dc.rights.licenceAttributionen
dc.rights.licenceAttributionen
lu.identifier.orcid0000-0003-1697-6916


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