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dc.contributor.authorJun, H.en
dc.contributor.authorKurenbach, B.en
dc.contributor.authorAitken, J.en
dc.contributor.authorWasa, A.en
dc.contributor.authorRemus-Emsermann, M. N. P.en
dc.contributor.authorGodsoe, Williamen
dc.contributor.authorHeinemann, J. A.en
dc.date.accessioned2019-05-13T03:32:08Z
dc.date.available2019-01-09en
dc.date.issued2019-01-09en
dc.identifier.citationJun et al. (2019). Effects of sub-lethal concentrations of copper ammonium acetate, pyrethrins and atrazine on the response of Escherichia coli to antibiotics [version 1; peer review: 2 approved, 1 approved with reservations]. F1000Research, 8,32. doi:10.12688/f1000research.17652.1en
dc.identifier.issn2046-1402en
dc.identifier.urihttps://hdl.handle.net/10182/10638
dc.description.abstractBackground: Antibiotic resistance in human and animal pathogens is mainly the outcome of human use of antibiotics. However, bacteria are also exposed to thousands of other antimicrobial agents. Increasingly those exposures are being investigated as co-selective agents behind the rapid rise and spread of resistance in bacterial pathogens of people and our domesticated animals. Methods: We measured the sub-lethal effects on antibiotic tolerance of the human pathogen/commensal Escherichia coli caused by exposure to three common biocide formulations based on either copper, pyrethrins, or atrazine as active ingredients. The influence of the efflux pump AcrAB-TolC was investigated using deletion strains, and the persistence of observed effects was determined. Results: Some effects were seen for all biocides, but the largest effects were observed with copper in combination with the antibiotic tetracycline. The effect was caused by both the induction of the adaptive efflux system and by chelation of the antibiotic by copper. Finally, persistence of the adaptive response was measured and found to persist for about two generations. Conclusions: Through a combination of microbe-chemical and chemical-chemical interactions, humanity may be creating micro-environments in which resistance evolution is accelerated.en
dc.format.extent16en
dc.languageengen
dc.language.isoenen
dc.publisherF1000Researchen
dc.relationThe original publication is available from - F1000Research - https://doi.org/10.12688/f1000research.17652.1en
dc.relation.urihttps://doi.org/10.12688/f1000research.17652.1en
dc.rights© 2019 Jun H et al.en
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en
dc.subjectbiocidesen
dc.subjectantibiotic resistant bacteriaen
dc.subjectantibioticsen
dc.subjectcopperen
dc.subjectpyrethrinsen
dc.subjectatrazineen
dc.titleEffects of sub-lethal concentrations of copper ammonium acetate, pyrethrins and atrazine on the response of Escherichia coli to antibiotics [version 1; peer review: 2 approved, 1 approved with reservations]en
dc.typeJournal Article
lu.contributor.unitLincoln Universityen
lu.contributor.unitBio-Protection Research Centreen
lu.contributor.unitResearch Management Officeen
lu.contributor.unit/LU/Research Management Office/2018 PBRF Staff groupen
dc.identifier.doi10.12688/f1000research.17652.1en
dc.subject.anzsrc0605 Microbiologyen
dc.subject.anzsrc060501 Bacteriologyen
dc.subject.anzsrc1108 Medical Microbiologyen
dc.relation.isPartOfF1000Researchen
pubs.notesArticle 32en
pubs.organisational-group/LU
pubs.organisational-group/LU/BPRC
pubs.organisational-group/LU/Research Management Office
pubs.organisational-group/LU/Research Management Office/2018 PBRF Staff group
pubs.publication-statusPublisheden
pubs.volume8en
dc.identifier.eissn2046-1402en
dc.rights.licenceAttributionen
dc.rights.licenceAttributionen
lu.identifier.orcid0000-0003-1697-6916


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