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dc.contributor.authorGreer, Andrew W.en
dc.contributor.authorSedcole, John R.en
dc.contributor.authorJay, Nigel P. W.en
dc.contributor.authorMcAnulty, Robin W.en
dc.contributor.authorGreen, R.en
dc.contributor.authorStankiewicz, M.en
dc.contributor.authorSykes, Andrew R.en
dc.date.accessioned2010-04-09T02:37:06Z
dc.date.issued2008-11en
dc.identifier.citationGreer, A. W., Sedcole, R. J., Jay, N. P., McAnulty, R. W., Green, R. S., Stankiewicz, M., et al. (2009). Protein supply influences the nutritional penalty associated with the development of immunity in lambs infected with Trichostrongylus colubriformis. Animal, 3(3), 437-445.en
dc.identifier.issn1751-7311en
dc.identifier.urihttps://hdl.handle.net/10182/1625
dc.description.abstractThe influence of dietary protein supply on the nutritional penalty associated with the acquisition phase of the immune response to gastrointestinal nematodes in lambs was investigated. Groups of lambs were offered either a low-protein diet (L; 62 g metabolizable protein (MP)/kg dry matter (DM)) or high-protein diet (H; 95 g MP/kg DM) while being either infected with the equivalent of 2.000 L3 Trichostrongylus colubriformis/day (IF), similarly infected and concurrently immuno-suppressed with methylprednisolone acetate (ISIF), immuno-suppressed only (IS) or kept as uninfected controls (C). Body composition of all animals was measured on days −8 and 76 of infection using X-ray computed tomography. Temporal changes in serum phosphate and serum albumin concentrations, which provided an indicator of pathological damage, in addition to patterns of total daily nematode egg excretion and comparative worm burdens at slaughter indicated that a protective immune response was developed in H-IF, but not L-IF, H-ISIF or L-ISIF groups. Compared to their respective non-infected controls, the gross efficiency of use of metabolizable energy (ME) for net energy (NE) deposition in the carcass was reduced by 0.23 in H-IF (P < 0.05), 0.13 in H-ISIF (P > 0.05), 0.49 in L-IF (P < 0.01) and 0.23 in L-ISIF (P > 0.05). It is concluded that the reduction in ME utilization and reduced performance, which can be attributed to the immunological response, are lessened in animals offered a high-protein diet. Furthermore, evidence is presented to indicate a possible association between T. colubriformis L3 IgA antibody production and loss of performance in lambs infected with this nematode.en
dc.format.extent437-445en
dc.language.isoenen
dc.publisherCambridge University Pressen
dc.relationThe original publication is available from - Cambridge University Pressen
dc.rightsCopyright © The Animal Consortium 2008en
dc.subjectnematodaen
dc.subjectimmuno-suppressionen
dc.subjectintakeen
dc.subjectsheepen
dc.subjectutilization of energyen
dc.subjectTrichostrongylus colubriformisen
dc.subjectDairy & Animal Scienceen
dc.titleProtein supply influences the nutritional penalty associated with the development of immunity in lambs infected with Trichostrongylus colubriformisen
dc.typeJournal Article
dc.subject.marsdenFields of Research::300000 Agricultural, Veterinary and Environmental Sciences::300400 Animal Production::300405 Animal production (pests and pathogens)en
lu.contributor.unitLincoln Universityen
lu.contributor.unitFaculty of Agriculture and Life Sciencesen
lu.contributor.unitDepartment of Agricultural Sciencesen
dc.subject.anzsrc06 Biological Sciencesen
dc.subject.anzsrc07 Agricultural and Veterinary Sciencesen
dc.relation.isPartOfAnimalen
pubs.issue3en
pubs.notesFirst published online 20 November 2008. Published in print March 2009.en
pubs.organisational-group/LU
pubs.organisational-group/LU/Agriculture and Life Sciences
pubs.organisational-group/LU/Agriculture and Life Sciences/AGSC
pubs.organisational-group/LU/Research Management Office
pubs.organisational-group/LU/Research Management Office/QE18
pubs.publication-statusPublisheden
pubs.volume3en
lu.identifier.orcid0000-0002-1479-3297
lu.identifier.orcid0000-0002-6234-0209


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