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    A model of magnesium metabolism in young sheep. Magnesium absorption and excretion

    Robson, Alexander B.; Field, A. C.; Sykes, Andrew R.; McKinnon, Alan E.
    Abstract
    A model of Mg metabolism in sheep is proposed. It is based on standard Michaelis-Menten enzyme kinetics to describe the transport of Mg across the rumen wall and passive diffusion to describe the absorption of Mg in the hindgut. Factors known to have an effect on Mg metabolism in farm animals, namely the concentrations of K and Mg in the diet, and the physico-chemical conditions within the rumen as determined by the type of diet, are incorporated into the model. Consideration of the rumen as the only site of Mg absorption provided an inadequate mechanistic description of Mg metabolism in sheep. To ensure compatibility between predicted Mg absorption and recent independent data sets for Mg balances, it was necessary to include in the model aspects of Mg absorption that operate in the hindgut. The results from this model suggest that there is a need for a series of experiments to determine the important aspects of Mg transport in the hindgut of sheep. Mechanisms of homeostasis are discussed.... [Show full abstract]
    Keywords
    magnesium; mathematical modelling; sheep; hypomagnesaemia; grass tetany; Nutrition & Dietetics; Intestinal Mucosa; Rumen; Animals; Magnesium Deficiency; Biological Transport; Homeostasis; Intestinal Absorption; Models, Biological
    Fields of Research
    0702 Animal Production; 0908 Food Sciences; 1111 Nutrition and Dietetics
    Date
    1997-12
    Type
    Journal Article
    Collections
    • Department of Agricultural Sciences [1407]
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    magnesium_metabolism.pdf
    DOI
    https://doi.org/10.1079/BJN19970213
    Metadata
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    Copyright © The Nutrition Society 1997
    Citation
    Robson, A. B., Field, A. C., Sykes, A. R., & McKinnon, A. E. (1997). A model of magnesium metabolism in young sheep. Magnesium absorption and excretion. British Journal of Nutrition, 78(6), 975-992.
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