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dc.contributor.authorNisbet, A. J.en
dc.contributor.authorMcNeilly, T. N.en
dc.contributor.authorGreer, Andrew W.en
dc.contributor.authorBartley, Y.en
dc.contributor.authorOliver, E. M.en
dc.contributor.authorSmith, S.en
dc.contributor.authorPalarea-Albaladejo, J.en
dc.contributor.authorMatthews, J. B.en
dc.date.accessioned2017-08-15T01:51:37Z
dc.date.available2016-09-04en
dc.date.issued2016-09-15en
dc.identifier.citationNisbet et al. (2016). Protection of ewes against Teladorsagia circumcincta infection in the periparturient period by vaccination with recombinant antigens. Veterinary Parasitology, 228, 130-136. doi:10.1016/j.vetpar.2016.09.002en
dc.identifier.issn0304-4017en
dc.identifier.urihttps://hdl.handle.net/10182/8416
dc.description.abstractTeladorsagiosis is a major production-limiting disease in ruminants in temperate regions throughout the world and one of the key interventions in the management of the disease is the prevention of pasture contamination with Teladorsagia circumcincta eggs by ewes during the periparturient relaxation in immunity which occurs in the period around lambing. Here, we describe the immunisation of twin-bearing ewes with a T. circumcincta recombinant subunit vaccine and the impact that vaccination has on their immune responses and shedding of parasite eggs during a continuous T. circumcincta challenge period spanning late gestation and lactation. In ewes which displayed a clear periparturient relaxation in immunity, vaccination resulted in a 45% reduction in mean cumulative faecal egg count (cFEC, p = 0.027) compared to control (immunised with adjuvant only) ewes. Recombinant antigen-specific IgG and IgA, which bound each of the vaccine antigens, were detected in the serum of vaccinated ewes following each immunisation and in colostrum taken from vaccinated ewes post-partum whereas low levels of antigen-specific IgG were detected in serum and colostrum from control ewes. Antigen-specific IgG and IgA levels in blood collected within 48 h of birth from lambs largely reflected those in the colostrum of their ewes.en
dc.format.extent130-136en
dc.language.isoenen
dc.publisherElsevieren
dc.relationThe original publication is available from - Elsevier - https://doi.org/10.1016/j.vetpar.2016.09.002 - http://dx.doi.org/10.1016/j.vetpar.2016.09.002en
dc.relation.urihttps://doi.org/10.1016/j.vetpar.2016.09.002en
dc.rights© 2016 The Authors. Published by Elsevier B.V. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).en
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/en
dc.subjectTeladorsagia circumcinctaen
dc.subjectrecombinant vaccineen
dc.subjectperiparturient perioden
dc.subjectMycology & Parasitologyen
dc.subject.meshFecesen
dc.subject.meshAnimalsen
dc.subject.meshSheepen
dc.subject.meshStrongylidaen
dc.subject.meshStrongylida Infectionsen
dc.subject.meshSheep Diseasesen
dc.subject.meshVaccines, Syntheticen
dc.subject.meshParasite Egg Counten
dc.subject.meshVaccinationen
dc.subject.meshLactationen
dc.subject.meshFemaleen
dc.titleProtection of ewes against Teladorsagia circumcincta infection in the periparturient period by vaccination with recombinant antigensen
dc.typeJournal Article
lu.contributor.unitLincoln Universityen
lu.contributor.unitFaculty of Agriculture and Life Sciencesen
lu.contributor.unitResearch Management Officeen
lu.contributor.unit/LU/Research Management Office/2018 PBRF Staff groupen
dc.identifier.doi10.1016/j.vetpar.2016.09.002en
dc.subject.anzsrc0605 Microbiologyen
dc.subject.anzsrc0704 Fisheries Sciencesen
dc.subject.anzsrc0707 Veterinary Sciencesen
dc.relation.isPartOfVeterinary Parasitologyen
pubs.notesAccepted 03 Sep 2016en
pubs.organisational-group/LU
pubs.organisational-group/LU/Agriculture and Life Sciences
pubs.organisational-group/LU/Research Management Office
pubs.organisational-group/LU/Research Management Office/2018 PBRF Staff group
pubs.publication-statusPublisheden
pubs.publisher-urlhttp://dx.doi.org/10.1016/j.vetpar.2016.09.002en
pubs.volume228en
dc.rights.licenceAttribution-NonCommercial-NoDerivativesen
lu.identifier.orcid0000-0002-1479-3297


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