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A new hierarchical approach to multi-level model abstraction for simplifying ODE models of biological networks and a case study: The G1/S Checkpoint/DNA damage signalling pathways of mammalian cell cycle
Model reduction is an important topic in studies of biological systems. By reducing the complexity of large models through multi-level models while keeping the essence (biological meaning) of the model, model reduction can ...
A comprehensive complex systems approach to the study and analysis of mammalian cell cycle control system in the presence of DNA damage stress
(Elsevier Ltd, 2017-09-21)
Not many models of mammalian cell cycle system exist due to its complexity. Some models are too complex and hard to understand, while some others are too simple and not comprehensive enough. Moreover, some essential aspects, ...