Now showing items 1-5 of 5
Inhibition of storage pathology in prenatal CLN5-deficient sheep neural cultures by lentiviral gene therapy
The neuronal ceroid lipofuscinoses (NCLs, Batten disease) are inherited neurodegenerative lysosomal storage diseases caused by mutations in several different genes. Mutations in CLN5 cause a variant late-infantile human ...
Identification of the ovine KAP11-1 gene (KRTAP11-1) and genetic variation in its coding sequence
Keratin-associated proteins (KAPs) are a structural component of the wool fibre and form the matrix between the keratin intermediate filaments (KIFs). The gene encoding high sulphur-protein KAP11-1 has been identified in ...
Diversity of the glycine/tyrosine-rich keratin-associated protein 6 gene (KAP6) family in sheep
Keratin-associated proteins (KAPs) are structural components of wool and variation in them may affect wool characteristics. In this study, we used PCR-SSCP to analyse the ovine KAP6 family which encodes glycine and ...
Conservation of complete trimethylation of lysine-43 in the rotor ring of c-subunits of metazoan adenosine triphosphate (ATP) synthases
(American Society for Biochemistry and Molecular Biology, 2015-04-01)
The rotors of ATP synthases turn about 100 times every second. One essential component of the rotor is a ring of hydrophobic c-subunits in the membrane domain of the enzyme. The rotation of these c-rings is driven by a ...
Identification and sequence analysis of the keratin-associated protein 24-1 (KAP24-1) gene homologue in sheep
Keratin-associated proteins (KAPs) are major structural components of hair and wool fibres, and play a critical role in determining the properties of the fibre. While over 100 KAP genes that have been grouped into 27 KAP ...