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The influence of rumen volatile fatty acids on protein metabolism in growing lambs
(Cambridge University Press (CUP), 1989-01-01)
The effect of acetic or propionic acid rumen fermentation patterns on whole-body protein turnover, tissue protein synthetic rates and body composition was investigated in growing lambs. Protein turnover was assessed using ...
Chronic oral administration of minocycline to sheep with ovine CLN6 neuronal ceroid lipofuscinosis maintains pharmacological concentrations in the brain but does not suppress neuroinflammation or disease progression
(BioMed Central, 2013-07-30)
Background: The neuronal ceroid lipofuscinoses (NCLs; or Batten disease) are fatal inherited human neurodegenerative diseases affecting an estimated 1:12,500 live births worldwide. They are caused by mutations in at least ...
Effects of calcium chloride, zinc chloride and water infusion on metmyoglobbin reducing activity and fresh lamb colour
(American Society of Animal Science, 2005)
Calcium chloride (CaCl2), zinc chloride (ZnCl2), or water infusions were used to investigate the biochemical factors that affect fresh lamb color, and to examine the role of metmyoglobin-reducing activity in regulating ...
Translational neurophysiology in sheep: Measuring sleep and neurological dysfunction in CLN5 Batten disease affected sheep
(Oxford University Press on behalf of the Guarantors of Brain, 2015-04-01)
Creating valid mouse models of slowly progressing human neurological diseases is challenging, not least because the short lifespan of rodents confounds realistic modelling of disease time course. With their large brains ...
Rapid and progressive regional brain atrophy in CLN6 batten disease affected sheep measured with longitudinal magnetic resonance imaging
(PLoS One, 2015-07-10)
Variant late-infantile Batten disease is a neuronal ceroid lipofuscinosis caused by mutations in CLN6. It is a recessive genetic lysosomal storage disease characterised by progressive neurodegeneration. It starts insidiously ...
Longitudinal in vivo monitoring of the CNS demonstrates the efficacy of gene therapy in a sheep model of CLN5 Batten disease
(Elsevier on behalf of the American Society of Gene and Cell Therapy, 2018-10-03)
Neuronal ceroid lipofuscinoses (NCLs; Batten disease) are neurodegenerative lysosomal storage diseases predominantly affecting children. Single administration of brain-directed lentiviral or recombinant single-stranded ...
The economic impact of eradicating Peste des Petits Ruminants: A benefit-cost analysis
(Public Library of Science, 2016-02-22)
Peste des petits ruminants (PPR) is an important cause of mortality and production loss among sheep and goats in the developing world. Despite control efforts in a number of countries, it has continued to spread across ...
Differentially phosphorylated proteins in the crimped and straight wool of Chinese Tan sheep
(Elsevier, 2021-03-20)
Proteins can be post-translationally modified and this can be important in the regulation of cellular processes and function. However, little is known about whether protein phosphorylation plays a role in regulating wool ...
The opportunity to eradicate Peste des petits ruminants
(American Association of Immunologists, 2016-05-01)
Peste des petits ruminants (PPR) is a highly infectious disease of sheep and goats that is caused by PPR virus, a member of the genus Morbillivirus that includes the viruses that cause rinderpest (RP) in cattle. RP was the ...
Refugia-based strategies for parasite control in livestock
(Elsevier, 2020-03)
Key points:
Refugia-based strategies are intended to help slow the development of anthelmintic resistance by leaving a population unexposed to a treatment.
Refugia can be supplied in several forms and through a variety of ...