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Does cortisol mediate endotoxin-induced inhibition of pulsatile luteinizing hormone and gonadotropin-releasing hormone secretion?
(Endocrine Society, 2002-10)
Bacterial endotoxin (lipopolysaccharide), a commonly used model of immune/inflammatory stress, inhibits reproductive neuroendocrine activity and concurrently induces a profound stimulation of the hypothalamo-pituitary-adrenal ...
C-type natriuretic peptide forms in pregnancy: maternal plasma profiles during ovine gestation correlate with placental and fetal maturation
(The Endocrine Society, 2009-10)
Circulating concentrations of C-type natriuretic peptide (CNP) and a related amino terminal fragment (NTproCNP) were measured at weekly intervals from preconception to 3 wk postpartum in ewes with twins (n = 8) and nonpregnant ...
Dexamethasone increases production of C-type natriuretic peptide in the sheep brain
(Bioscientifica Ltd on behalf of the Society for Endocrinology, 2017-10-01)
Although C-type natriuretic peptide (CNP) has high abundance in brain tissues and cerebrospinal fluid (CSF), the source and possible factors regulating its secretion within the central nervous system (CNS) are unknown. ...
A nucleotide substitution in exon 8 of the glucosylceramidase beta gene is associated with Gaucher disease in sheep
(Wiley on behalf of Stichting International Foundation for Animal Genetics and the International Society for Animal Genetics, 2017-12)
Gaucher disease is an autosomal recessive disorder caused by deficiency of the enzyme glucosylceramidase beta (GBA; EC 3.2.1.45). Human Gaucher disease is caused by mutations in the GBA gene, and nearly 300 mutations have ...
Sustained increases in plasma C-type natriuretic peptides fail to increase concentrations in cerebrospinal fluid: Evidence from pregnant sheep
(Elsevier Inc, 2015-07)
C-type natriuretic peptide (CNP) is a paracrine growth factor with high abundance in CNS tissues and cerebrospinal fluid (CSF). Consistent with findings of CNP transcripts in the cerebral microvasculature and hypothalamus, ...
Differential response of C-type natriuretic peptide to estrogen and dexamethasone in adult bone
(Elsevier, 2014-09)
C-type natriuretic peptide (CNP) is crucial in promoting endochondral bone growth in mammals including humans but whether this paracrine hormone participates in maintaining bone integrity in the mature skeleton is unknown. ...
Direct anthelmintic and immunostimulatory effects of oral dosing semi-purified phytohaemagglutinin lectin in sheep infected with Teladorsagia circumcincta and Trichostrongylus colubriformis
(Elsevier B.V. on behalf of the American Association of Veterinary Parasitologists (AAVP), the European Veterinary Parasitology College (EVPC), and the World Association for the Advancement of Veterinary Parasitology (WAAVP), 2012-06-08)
Lectins are plant secondary compounds that can have anthelmintic properties in vitro. In particular, the phytohaemagglutinin lectin extracted from Phaseolus vulgaris has been shown to inhibit the feeding of Trichostrongylus ...
Effect of variation in ovine WFIKKN₂ on growth traits appears to be gender-dependent
(Macmillan Publishers Limited, part of Springer Nature., 2015-07-22)
WFIKKN₂ may play a role in the regulation of muscle growth and development, but to date there have been no reports on the effect of variation in WFIKKN₂ on growth and carcass traits in livestock. In this study, the effect ...
Elevation of feed intake in parasite-infected lambs by central administration of a cholecystokinin receptor antagonist
(Cambridge University Press, 1998-01)
The role of cholecystokinin (CCK) in modulating feed intake depression in parasite-infected lambs was investigated using CCK receptor antagonists (L364–718 and loxiglumide). Four experiments were carried out using ewe lambs ...
Protection of ewes against Teladorsagia circumcincta infection in the periparturient period by vaccination with recombinant antigens
(Elsevier, 2016-09-15)
Teladorsagiosis is a major production-limiting disease in ruminants in temperate regions throughout the world and one of the key interventions in the management of the disease is the prevention of pasture contamination ...