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A nucleotide substitution in exon 8 of the glucosylceramidase beta gene is associated with Gaucher disease in sheep
(Wiley on behalf of Stichting International Foundation for Animal Genetics and the International Society for Animal Genetics, 2017-12)
Gaucher disease is an autosomal recessive disorder caused by deficiency of the enzyme glucosylceramidase beta (GBA; EC 3.2.1.45). Human Gaucher disease is caused by mutations in the GBA gene, and nearly 300 mutations have ...
Consumption of sheep milk compared to cow milk can affect trabecular bone ultrastructure in a rat model
(The Royal Society of Chemistry, 2019-01-01)
Cow milk has a positive effect on bone health due to the effects of its protein, fat, lipid, vitamin, and mineral components. Sheep milk contains a unique composition of all of these components. However, to the best of our ...
Direct anthelmintic and immunostimulatory effects of oral dosing semi-purified phytohaemagglutinin lectin in sheep infected with Teladorsagia circumcincta and Trichostrongylus colubriformis
(Elsevier B.V. on behalf of the American Association of Veterinary Parasitologists (AAVP), the European Veterinary Parasitology College (EVPC), and the World Association for the Advancement of Veterinary Parasitology (WAAVP), 2012-06-08)
Lectins are plant secondary compounds that can have anthelmintic properties in vitro. In particular, the phytohaemagglutinin lectin extracted from Phaseolus vulgaris has been shown to inhibit the feeding of Trichostrongylus ...
Effect of variation in ovine WFIKKN₂ on growth traits appears to be gender-dependent
(Macmillan Publishers Limited, part of Springer Nature., 2015-07-22)
WFIKKN₂ may play a role in the regulation of muscle growth and development, but to date there have been no reports on the effect of variation in WFIKKN₂ on growth and carcass traits in livestock. In this study, the effect ...
Chronic oral administration of minocycline to sheep with ovine CLN6 neuronal ceroid lipofuscinosis maintains pharmacological concentrations in the brain but does not suppress neuroinflammation or disease progression
(BioMed Central, 2013-07-30)
Background: The neuronal ceroid lipofuscinoses (NCLs; or Batten disease) are fatal inherited human neurodegenerative diseases affecting an estimated 1:12,500 live births worldwide. They are caused by mutations in at least ...
Rapid and progressive regional brain atrophy in CLN6 batten disease affected sheep measured with longitudinal magnetic resonance imaging
(PLoS One, 2015-07-10)
Variant late-infantile Batten disease is a neuronal ceroid lipofuscinosis caused by mutations in CLN6. It is a recessive genetic lysosomal storage disease characterised by progressive neurodegeneration. It starts insidiously ...
Two single nucleotide polymorphisms in the promoter of the ovine myostatin gene (MSTN) and their effect on growth and carcass muscle traits in New Zealand Romney sheep
(Wiley, 2016-06)
Myostatin is a negative regulator of muscle growth and development in mammals, and variation in ovine myostatin gene (MSTN) has been demonstrated to be associated with variation in the muscularity of sheep. Polymerase chain ...
Comparison of the timing of development of immunity in Romney lambs from resistant and resilient selection lines
(Elsevier on behalf of the American Association of Veterinary Parasitologists (AAVP), European Veterinary Parasitology College (EVPC), and the World Association for the Advancement of Veterinary Parasitology (WAAVP), 2019-06)
Variation in the timing of development of immunity to gastro-intestinal nematode parasites was assessed in resistant and resilient Romney selection lines exposed to mixed natural infection. From weaning, at mean 92 ...
The effect of dietary sainfoin (Onobrychis viciifolia) on local cellular responses to Trichostrongylus colubriformis in sheep
(Cambridge University Press, 2008-08)
The effect of sainfoin (Onobrychis viciifolia) hay consumption on the pathophysiology and local cellular responses of growing lambs during infection with Trichostrongylus colubriformis was investigated. Thirty-two lambs, ...
An evaluation of plasma homocysteine in the assessment of vitamin B12 status of pasture-fed sheep
(New Zealand Veterinary Association, 2010)
Homocysteine (Hcy) is a component of metabolic pathways that are associated with the exchange of methyl groups vital to the animal's survival. Vitamin B₁₂ (cobalamin) has a key role in these methylation reactions and the ...