Publication

The development of brain magnetic resonance approaches in large animal models for preclinical research

Authors
Ella, A, Barrière, DA, Adriaensen, H, Palmer, DN, Melzer, TR, Mitchell, Nadia, Keller, M
Date
2019-07
Type
Journal Article
Collections
Department of Wine, Food and Molecular Biosciences
Keywords
brain, image analysis, magnetic resonance imaging, pathology
Fields of Research
ANZSRC::320601 Gene and molecular therapy, ANZSRC::320905 Neurology and neuromuscular diseases, ANZSRC::320222 Radiology and organ imaging, ANZSRC::310906 Animal neurobiology, ANZSRC::320903 Central nervous system, ANZSRC::3003 Animal production, ANZSRC::3009 Veterinary sciences
Abstract
• Magnetic resonance imaging is a very powerful approach to perform anatomical and functional imaging explorations. • Large animal models are perfectly suited for MRI studies using clinical devices and these tools are currently being developed and improved. • Here we highlight an example of MRI to demonstrate the efficacy of gene therapy in sheep models of Batten disease, a pediatric neurodegenerative disease.
Files
Name: Ella et al 2019 The development of brain magnetic resonance approaches.pdf
Size: 10.57 MB
Kind: Adobe PDF
Permalink
https://hdl.handle.net/10182/14656
Source DOI
10.1093/af/vfz024
Rights
© Ella, Barrière, Adriaenssen, Palmer, Melzer, Mitchell, and Keller.
Creative Commons Rights
Attribution-NonCommercial
cbn
Access Rights
Full item page