Susceptibility of ovine lens crystallins to proteolytic cleavage by calpain during cataract formation: a 2-DE approach

Abstract

In humans, cataracts are a major cause of blindness. As such, extensive research is being pursued to elucidate the exact mechanism by which cataracts form. Currently many people endure risky operations to remove the cataract-affected lens, which impedes vision. An understanding of the process of cataractogenesis may uncover an alternative, less invasive treatment.