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dc.contributor.authorAlvarez, L.en
dc.contributor.authorGreer, Andrew W.en
dc.contributor.authorJackson, F.en
dc.contributor.authorAthanasiadou, S.en
dc.contributor.authorKyriazakis, I.en
dc.contributor.authorHuntley, J.en
dc.date.accessioned2009-07-24T03:10:41Z
dc.date.issued2008-08en
dc.identifier.citationRíos de Álvarez, L., Greer, A. W., Jackson, F., Athanasiadou. S., Kyriazakis, I., & Huntley, J. F. (2008). The effect of dietary sainfoin (Onobrychis viciifolia) on local cellular responses to Trichostrongylus colubriformis in sheep. Parasitology, 135(9), 1117-1124.en
dc.identifier.issn0031-1820en
dc.identifier.urihttps://hdl.handle.net/10182/1133
dc.description.abstractThe effect of sainfoin (Onobrychis viciifolia) hay consumption on the pathophysiology and local cellular responses of growing lambs during infection with Trichostrongylus colubriformis was investigated. Thirty-two lambs, 16 weeks of age, were allocated to 1 of 4 treatment groups (n=8) that were offered either grass (G) or sainfoin (S) hay while concurrently either infected (+), or not (−) with 12 000 L3 T. colubriformis larvae per week for 6 weeks. Liveweight gains were affected by diet (P=0·002) and reduced by infection (P<0·005). Faecal egg count was reduced in S+ compared to G+ from days 35 to 42 (P=0·001); however, total egg output, worm burdens at day 42 and worm fecundity were similar between diets (P>0·05). Feeding sainfoin appeared to enhance immune cell development with tissue eosinophils, mast cells and pan T cells present in greater concentrations in S+ than in G+ animals. However, further studies are required to determine if the enhanced immune cell development is a consequence of a greater nutrient supply or a direct influence of sainfoin metabolites on local inflammatory responses to the gastrointestinal nematode T. colubriformis.en
dc.format.extent1117-1124en
dc.language.isoenen
dc.publisherCambridge University Pressen
dc.relationThe original publication is available from - Cambridge University Pressen
dc.rightsCopyright © 2008 Cambridge University Pressen
dc.subjectsainfoinen
dc.subjectOnobrychis viciifoliaen
dc.subjectTrichostrongylus colubriformisen
dc.subjectplant secondary metabolites (PSM)en
dc.subjectlocal immune responseen
dc.subjectnematodesen
dc.subjectsheepen
dc.subjectMycology & Parasitologyen
dc.subject.meshAnimalsen
dc.subject.meshTrichostrongylusen
dc.subject.meshFabaceaeen
dc.subject.meshBody Weighten
dc.subject.meshParasite Egg Counten
dc.subject.meshAnimal Feeden
dc.subject.meshFemaleen
dc.subject.meshMaleen
dc.subject.meshHost-Parasite Interactionsen
dc.titleThe effect of dietary sainfoin (Onobrychis viciifolia) on local cellular responses to Trichostrongylus colubriformis in sheepen
dc.typeJournal Article
dc.subject.marsdenFields of Research::300000 Agricultural, Veterinary and Environmental Sciences::300400 Animal Production::300405 Animal production (pests and pathogens)en
dc.subject.marsdenFields of Research::300000 Agricultural, Veterinary and Environmental Sciences::300500 Veterinary Medicine::300508 Parasitologyen
lu.contributor.unitLincoln Universityen
lu.contributor.unitFaculty of Agriculture and Life Sciencesen
lu.contributor.unitDepartment of Agricultural Sciencesen
lu.contributor.unitResearch Management Officeen
lu.contributor.unit/LU/Research Management Office/2018 PBRF Staff groupen
dc.subject.anzsrc0707 Veterinary Sciencesen
dc.relation.isPartOfParasitologyen
pubs.organisational-group/LU
pubs.organisational-group/LU/Agriculture and Life Sciences
pubs.organisational-group/LU/Agriculture and Life Sciences/AGSC
pubs.organisational-group/LU/Research Management Office
pubs.organisational-group/LU/Research Management Office/2018 PBRF Staff group
pubs.publication-statusPublisheden
pubs.volume135en
lu.identifier.orcid0000-0002-1479-3297


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