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    Cellular biological activity and regulation of gene expression of antioxidant dietary fibre fraction isolated from blackcurrant incorporated in the wholemeal cereals cookies

    Hossain, M; Brennan, Margaret; Guo, Xinbo,; Zeng, X-A; Brennan, CS
    Abstract
    Free and bound phenolics were extracted from the fibre fraction of wholemeal (W) wheat and barley (B) cookies which had been fortified with 15% blackcurrant powder. Blackcurrant enriched cookies contained between 55 and 66 % higher total phenolics respectively compared control cookies. Ferulic acid in wheat and barley cookie extracts, and quercetin and kaempferol-3-glucoside in wheat cookies with 15% blackcurrant were the dominant phenolic acids. Cellular antioxidant activity was higher in samples with blackcurrant inclusion when evaluated in a cancer cell HepG2 model. Inhibition of cell proliferation was lower for the phenolic samples from cookies with blackcurrant addition. These samples suppressed the regulation of inflammatory cytokine IL-1β (about 3 to 4-fold), IL-6 (about 2-fold) and transcription signalling factor NF-kB (about 2-fold) and showed an up-regulation of the satiety gene NUCB-2/nesfatin-1 (about 4-fold) in compared with control samples.... [Show full abstract]
    Keywords
    antioxidant-DF; phenolic acid; cellular antioxidant analysis; antiproliferation; inflammatory cytokine; satiety gene; Humans; Hordeum; Triticum; Ribes; Phenols; Antioxidants; Gene Expression Regulation; Dietary Fiber; Edible Grain; Antioxidants; Dietary Fiber; Edible Grain; Gene Expression Regulation; Hordeum; Humans; Phenols; Ribes; Triticum
    Date
    2020-05-15
    Type
    Journal Article
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    DOI
    https://doi.org/10.1016/j.foodchem.2019.125829
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