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dc.contributor.authorKurenbach, B.en
dc.contributor.authorHill, A. M.en
dc.contributor.authorGodsoe, Williamen
dc.contributor.authorvan Hamelsveld, S.en
dc.contributor.authorHeinemann, J. A.en
dc.date.accessioned2020-05-25T02:50:29Z
dc.date.issued2018-10-12en
dc.date.submitted2018-09-21en
dc.identifier.issn2167-8359en
dc.identifier.urihttps://hdl.handle.net/10182/11923
dc.description.abstractAntibiotic resistance in our pathogens is medicine's climate change: Caused by human activity, and resulting in more extreme outcomes. Resistance emerges in microbial populations when antibiotics act on phenotypic variance within the population. This can arise from either genotypic diversity (resulting from a mutation or horizontal gene transfer), or from differences in gene expression due to environmental variation, referred to as adaptive resistance. Adaptive changes can increase fitness allowing bacteria to survive at higher concentrations of antibiotics. They can also decrease fitness, potentially leading to selection for antibiotic resistance at lower concentrations. There are opportunities for other environmental stressors to promote antibiotic resistance in ways that are hard to predict using conventional assays. Exploiting our previous observation that commonly used herbicides can increase or decrease the minimum inhibitory concentration (MIC) of different antibiotics, we provide the first comprehensive test of the hypothesis that the rate of antibiotic resistance evolution under specified conditions can increase, regardless of whether a herbicide increases or decreases the antibiotic MIC. Short term evolution experiments were used for various herbicide and antibiotic combinations. We found conditions where acquired resistance arises more frequently regardless of whether the exogenous non-antibiotic agent increased or decreased antibiotic effectiveness. This is attributed to the effect of the herbicide on either MIC or the minimum selective concentration (MSC) of a paired antibiotic. The MSC is the lowest concentration of antibiotic at which the fitness of individuals varies because of the antibiotic, and is lower than MIC. Our results suggest that additional environmental factors influencing competition between bacteria could enhance the ability of antibiotics to select antibiotic resistance. Our work demonstrates that bacteria may acquire antibiotic resistance in the environment at rates substantially faster than predicted from laboratory conditions.en
dc.format.extent20en
dc.language.isoenen
dc.publisherPeerJen
dc.relationThe original publication is available from - PeerJ - https://doi.org/10.7717/peerj.5801en
dc.relation.urihttps://doi.org/10.7717/peerj.5801en
dc.rights© 2018 Kurenbach et al.en
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en
dc.subjectantibiotic resistanceen
dc.subjectherbicideen
dc.subjectminimum selective concentrationen
dc.subjectadaptive resistanceen
dc.subjectevolutionen
dc.titleAgrichemicals and antibiotics in combination increase antibiotic resistance evolutionen
dc.typeJournal Article
lu.contributor.unitLincoln Universityen
lu.contributor.unitBio-Protection Research Centreen
dc.identifier.doi10.7717/peerj.5801en
dc.subject.anzsrc06 Biological Sciencesen
dc.subject.anzsrc11 Medical and Health Sciencesen
dc.subject.anzsrc079902 Fertilisers and Agrochemicals (incl. Application)en
dc.relation.isPartOfPeerJen
pubs.issue10en
pubs.notesA Preprint version of this peer-reviewed article exists and was first published online 10 May 2018– see doi.org/10.7287/peerj.preprints.26925v1 and https://peerj.com/preprints/26925v1en
pubs.organisational-group/LU
pubs.organisational-group/LU/BPRC
pubs.organisational-group/LU/Research Management Office
pubs.organisational-group/LU/Research Management Office/QE18
pubs.publication-statusPublisheden
pubs.volume2018en
dc.identifier.eissn2167-8359en
dc.rights.licenceAttributionen
dc.rights.licenceAttributionen
lu.identifier.orcid0000-0003-1697-6916


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