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dc.contributor.authorHo, S
dc.contributor.authorWoodford, Keith
dc.contributor.authorKukuljan, S
dc.contributor.authorPal, S
dc.coverage.spatialEngland
dc.date.accessioned2020-06-16T02:37:13Z
dc.date.available2014-07-02
dc.date.issued2014-07-02
dc.date.submitted2014-05-24
dc.identifierejcn2014127
dc.identifierhttp://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000341168600004&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=42fe17854fe8be72a22db98beb5d2208
dc.identifier.issn0954-3007
dc.identifier.otherAO2PV (isidoc)
dc.identifier.other24986816 (pubmed)
dc.identifier.urihttps://hdl.handle.net/10182/12078
dc.description.abstractAt present, there is debate about the gastrointestinal effects of A1-type beta-casein protein in cows' milk compared with the progenitor A2 type. In vitro and animal studies suggest that digestion of A1 but not A2 beta-casein affects gastrointestinal motility and inflammation through the release of beta-casomorphin-7. We aimed to evaluate differences in gastrointestinal effects in a human adult population between milk containing A1 versus A2 beta-casein. Forty-one females and males were recruited into this double-blinded, randomised 8-week cross-over study. Participants underwent a 2-week dairy washout (rice milk replaced dairy), followed by 2 weeks of milk (750 ml/day) that contained beta-casein of either A1 or A2 type before undergoing a second washout followed by a final 2 weeks of the alternative A1 or A2 type milk. The A1 beta-casein milk led to significantly higher stool consistency values (Bristol Stool Scale) compared with the A2 beta-casein milk. There was also a significant positive association between abdominal pain and stool consistency on the A1 diet (r=0.520, P=0.001), but not the A2 diet (r=-0.13, P=0.43). The difference between these two correlations (0.52 versus -0.13) was highly significant (P < 0.001). Furthermore, some individuals may be susceptible to A1 beta-casein, as evidenced by higher faecal calprotectin values and associated intolerance measures. These preliminary results suggest differences in gastrointestinal responses in some adult humans consuming milk containing beta-casein of either the A1 or the A2 beta-casein type, but require confirmation in a larger study of participants with perceived intolerance to ordinary A1 beta-casein-containing milk.
dc.format.extentpp.994-1000
dc.format.mediumPrint-Electronic
dc.languageen
dc.language.isoen
dc.publisherMacmillan Publishers Limited
dc.relationThe original publication is available from Macmillan Publishers Limited - https://doi.org/10.1038/ejcn.2014.127
dc.relation.urihttps://doi.org/10.1038/ejcn.2014.127
dc.rights© 2014 Macmillan Publishers Limited
dc.subjectA1 beta-casein
dc.subjectA2 beta-casein
dc.subjectmilk
dc.subjectmilk digestion
dc.subjectdietary intolerance
dc.subject.meshGastrointestinal Tract
dc.subject.meshMilk
dc.subject.meshFeces
dc.subject.meshAnimals
dc.subject.meshCattle
dc.subject.meshHumans
dc.subject.meshAbdominal Pain
dc.subject.meshEndorphins
dc.subject.meshPeptide Fragments
dc.subject.meshLeukocyte L1 Antigen Complex
dc.subject.meshCaseins
dc.subject.meshPilot Projects
dc.subject.meshCross-Over Studies
dc.subject.meshDouble-Blind Method
dc.subject.meshDigestion
dc.subject.meshAdult
dc.subject.meshAged
dc.subject.meshMiddle Aged
dc.subject.meshFemale
dc.subject.meshMale
dc.subject.meshYoung Adult
dc.subject.meshAbdominal Pain
dc.subject.meshAdult
dc.subject.meshAged
dc.subject.meshAnimals
dc.subject.meshCaseins
dc.subject.meshCattle
dc.subject.meshCross-Over Studies
dc.subject.meshDigestion
dc.subject.meshDouble-Blind Method
dc.subject.meshEndorphins
dc.subject.meshFeces
dc.subject.meshFemale
dc.subject.meshGastrointestinal Tract
dc.subject.meshHumans
dc.subject.meshLeukocyte L1 Antigen Complex
dc.subject.meshMale
dc.subject.meshMiddle Aged
dc.subject.meshMilk
dc.subject.meshPeptide Fragments
dc.subject.meshPilot Projects
dc.subject.meshYoung Adult
dc.titleComparative effects of A1 versus A2 beta-casein on gastrointestinal measures: A blinded randomised cross-over pilot study
dc.typeJournal Article
lu.contributor.unitLincoln University
lu.contributor.unitFaculty of Agribusiness and Commerce
lu.contributor.unitDepartment of Land Management and Systems
dc.identifier.doi10.1038/ejcn.2014.127
dc.relation.isPartOfEuropean Journal of Clinical Nutrition
pubs.issue9
pubs.organisational-group|LU
pubs.organisational-group|LU|Faculty of Agribusiness and Commerce
pubs.organisational-group|LU|Faculty of Agribusiness and Commerce|LAMS
pubs.publication-statusPublished
pubs.volume68
dc.identifier.eissn1476-5640


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