Oleic acid alleviates cadmium-induced oxidative damage in rat by its radicals scavenging activity
Wang, Jingwen; Zhang, Yuanyuan; Fang, Zhijia; Sun, Lijun; Wang, Yaling; Liu, Ying; Xu, Defeng; Nie, Fanghong; Gooneratne, Sarojith R.
Toxic heavy metal cadmium wildly pollutes the environment and threats the human health. Effective treatment of cadmium-induced toxicity and organ damage is an important issue. Cadmium causes organ damage through inducing oxidative stress. Our previous study also found oleic acid (OA) synthesis-related gene can confer resistance to cadmium and alleviate cadmium-induced stress in yeast. However, its alleviation mechanism on cadmium stress especially in animals is still unclear. In this study, the alleviative effects of OA on cadmium and cadmium-induced oxidative stress in rats were investigated. Oral administration of 10, 20, and 30 mg/kg/day OA can significantly increase the survival rate of rats intraperitoneally injected with 30 mg/kg/day cadmium continuously for 7 days. Similar to ascorbic acid (AA), OA can significantly reduce the cadmium-induced lipid peroxidation in multiple organs of rats. The investigation of OA on superoxide dismutase (SOD) activity showed that OA increased the SOD activity of cadmium-treated rat organs. More important, OA reduced the level of superoxide radical O2−of cadmium-treated rat organs. And OA exhibited a strong DPPH radicals scavenging activity at dose of 10, 20 and 30 mg/mL, which may contributed to alleviating cadmium-induced oxidative stress. This study revealed that OA could significantly alleviate cadmium stress via reducing cadmium-induced lipid peroxidation and SOD activity inhibition through its radicals scavenging activity.... [Show full abstract]
Keywordsoleic acid; cadmium; oxidation stress; antioxidation; radicals scavenging activity; Toxicology; Animals; Rats; Cadmium Poisoning; Ascorbic Acid; Catalase; Superoxide Dismutase; Antioxidants; Lipid Peroxidation; Oxidative Stress; Male
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