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dc.contributor.authorWang, Jingwen
dc.contributor.authorZhang, Yuanyuan
dc.contributor.authorFang, Zhijia
dc.contributor.authorSun, Lijun
dc.contributor.authorWang, Yaling
dc.contributor.authorLiu, Ying
dc.contributor.authorXu, Defeng
dc.contributor.authorNie, Fanghong
dc.contributor.authorGooneratne, Sarojith R.
dc.date.accessioned2020-10-04T21:33:19Z
dc.date.available2018-09-29en
dc.date.issued2019-07-15
dc.date.submitted2018-09-14en
dc.identifier.issn0163-4984en
dc.identifier.urihttps://hdl.handle.net/10182/12890
dc.description.abstractToxic heavy metal cadmium wildly pollutes the environment and threats the human health. Effective treatment of cadmium-induced toxicity and organ damage is an important issue. Cadmium causes organ damage through inducing oxidative stress. Our previous study also found oleic acid (OA) synthesis-related gene can confer resistance to cadmium and alleviate cadmium-induced stress in yeast. However, its alleviation mechanism on cadmium stress especially in animals is still unclear. In this study, the alleviative effects of OA on cadmium and cadmium-induced oxidative stress in rats were investigated. Oral administration of 10, 20, and 30 mg/kg/day OA can significantly increase the survival rate of rats intraperitoneally injected with 30 mg/kg/day cadmium continuously for 7 days. Similar to ascorbic acid (AA), OA can significantly reduce the cadmium-induced lipid peroxidation in multiple organs of rats. The investigation of OA on superoxide dismutase (SOD) activity showed that OA increased the SOD activity of cadmium-treated rat organs. More important, OA reduced the level of superoxide radical O2−of cadmium-treated rat organs. And OA exhibited a strong DPPH radicals scavenging activity at dose of 10, 20 and 30 mg/mL, which may contributed to alleviating cadmium-induced oxidative stress. This study revealed that OA could significantly alleviate cadmium stress via reducing cadmium-induced lipid peroxidation and SOD activity inhibition through its radicals scavenging activity.en
dc.format.extent95-100en
dc.language.isoen
dc.publisherSpringer
dc.relationThe original publication is available from - Springer - https://doi.org/10.1007/s12011-018-1526-4en
dc.relation.urihttps://doi.org/10.1007/s12011-018-1526-4en
dc.rights© Springer Science+Business Media, LLC, part of Springer Nature 2018
dc.subjectoleic aciden
dc.subjectcadmiumen
dc.subjectoxidation stressen
dc.subjectantioxidationen
dc.subjectradicals scavenging activityen
dc.subjectToxicologyen
dc.subject.meshAnimalsen
dc.subject.meshRatsen
dc.subject.meshCadmium Poisoningen
dc.subject.meshAscorbic Aciden
dc.subject.meshCatalaseen
dc.subject.meshSuperoxide Dismutaseen
dc.subject.meshAntioxidantsen
dc.subject.meshLipid Peroxidationen
dc.subject.meshOxidative Stressen
dc.subject.meshMaleen
dc.titleOleic acid alleviates cadmium-induced oxidative damage in rat by its radicals scavenging activityen
dc.typeJournal Article
lu.contributor.unitLincoln University
lu.contributor.unitFaculty of Agriculture and Life Sciences
lu.contributor.unitDepartment of Wine, Food and Molecular Biosciences
dc.identifier.doi10.1007/s12011-018-1526-4en
dc.relation.isPartOfBiological Trace Element Researchen
pubs.organisational-group/LU
pubs.organisational-group/LU/Agriculture and Life Sciences
pubs.organisational-group/LU/Agriculture and Life Sciences/WFMB
pubs.organisational-group/LU/Research Management Office
pubs.organisational-group/LU/Research Management Office/QE18
pubs.publication-statusPublisheden
pubs.volume190en
dc.identifier.eissn1559-0720en
lu.identifier.orcid0000-0002-5406-2894


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