Show simple item record

dc.contributor.authorBhardwaj, Piyush
dc.contributor.authorKulasiri, Gamalathge D.
dc.contributor.authorSamarasinghe, Sandhya
dc.date.accessioned2021-01-25T21:25:27Z
dc.date.available2020-10-09en
dc.date.issued2021-04
dc.date.submitted2020-05-20en
dc.identifier.issn1673-5374en
dc.identifier.urihttps://hdl.handle.net/10182/13269
dc.description.abstractThe axon initial segment (AIS) region is crucial for action potential initiation due to the presence of high-density AIS protein voltage-gated sodium channels (Naᵥ). Naᵥ channels comprise several serine residues responsible for the recruitment of Naᵥ channels into the structure of AIS through interactions with ankyrin-G (AnkG). In this study, a series of computational experiments are performed to understand the role of AIS proteins casein kinase 2 and AnkG on Naᵥ channel recruitment into the AIS. The computational simulation results using Virtual cell software indicate that Naᵥ channels with all serine sites available for phosphorylation bind to AnkG with strong affinity. At the low initial concentration of AnkG and casein kinase 2, the concentration of Naᵥ channels reduces significantly, suggesting the importance of casein kinase 2 and AnkG in the recruitment of Naᵥ channels.en
dc.format.extent700-706 (7)en
dc.language.isoen
dc.publisherWolters Kluwer Medknow Publications
dc.relationThe original publication is available from - Wolters Kluwer Medknow Publications - https://doi.org/10.4103/1673-5374.295332en
dc.relation.urihttps://doi.org/10.4103/1673-5374.295332en
dc.rights© 2020. Neural Regeneration Research. Wolters Kluwer Medknow Publications
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/4.0/en
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/4.0/en
dc.subjectAlzheimer’s diseaseen
dc.subjectankyrin-Gen
dc.subjectaxon initial segmenten
dc.subjectcasein kinase-2en
dc.subjectmicrotubulesen
dc.subjectvoltage-gated potassium channelen
dc.subjectvoltage-gated sodium channelen
dc.subjectAlzheimer's diseaseen
dc.titleModeling protein-protein interactions in axon initial segment to understand their potential impact on action potential initiationen
dc.typeJournal Article
lu.contributor.unitLincoln University
lu.contributor.unitFaculty of Agriculture and Life Sciences
lu.contributor.unitDepartment of Wine, Food and Molecular Biosciences
lu.contributor.unitFaculty of Environment, Society and Design
lu.contributor.unitDepartment of Environmental Management
dc.identifier.doi10.4103/1673-5374.295332en
dc.subject.anzsrc080110 Simulation and Modellingen
dc.subject.anzsrc030402 Biomolecular Modelling and Designen
dc.subject.anzsrc110904 Neurology and Neuromuscular Diseasesen
dc.subject.anzsrc080108 Neural, Evolutionary and Fuzzy Computationen
dc.relation.isPartOfNeural Regeneration Researchen
pubs.issue4en
pubs.organisational-group/LU
pubs.organisational-group/LU/Agriculture and Life Sciences
pubs.organisational-group/LU/Agriculture and Life Sciences/WFMB
pubs.organisational-group/LU/Faculty of Environment, Society and Design
pubs.organisational-group/LU/Faculty of Environment, Society and Design/DEM
pubs.organisational-group/LU/Research Management Office
pubs.organisational-group/LU/Research Management Office/QE18
pubs.publication-statusPublished onlineen
pubs.volume16en
dc.identifier.eissn1876-7958en
dc.rights.licenceAttribution-NonCommercial-ShareAlikeen
dc.rights.licenceAttribution-NonCommercial-ShareAlikeen
lu.identifier.orcid0000-0001-8744-1578
lu.identifier.orcid0000-0003-2943-4331


Files in this item

Default Thumbnail

This item appears in the following Collection(s)

Show simple item record

Creative Commons Attribution-NonCommercial-ShareAlikeCreative Commons Attribution-NonCommercial-ShareAlike
Except where otherwise noted, this item's license is described as Creative Commons Attribution-NonCommercial-ShareAlikeCreative Commons Attribution-NonCommercial-ShareAlike