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dc.contributor.authorLi, Yunhaien
dc.contributor.authorZhou, Huitongen
dc.contributor.authorCheng, L.en
dc.contributor.authorZhao, Jenny H.en
dc.contributor.authorHickford, Jonathan G. H.en
dc.description.abstractGene markers have become useful tools for improving animal genetics and breeding since they improve the accuracy of selection for superior breeding stock. In this study, the stearoyl-CoA desaturase (Δ-9-desaturase) gene (SCD) was investigated in New Zealand pasture-grazed Holstein-Friesian × Jersey cows. Three nucleotide substitutions were identified in exon 5 of the gene (c.702A/G, c.762T/C and c.878C/T), and a single nucleotide substitution was identified in intron 5 (c.880C105A/G). The c.878C/T substitution would, if expressed, result in the amino acid substitution p.A293V. Four nucleotide substitutions (c.∗1783A/G, c.∗1883C/T, c.∗1984G/A and c.∗2066T/C/G) were identified in the 30-untranslated region (3′-UTR), and these resulted in three nucleotide sequence variants (named a, b and c). The sequence that would encode valine (V) at position 293 of SCD was linked to 3′-UTR variant a, and the sequence that would encode alanine (A) was linked to variants b and c. The frequency of the genotypes was as follows: VV (equivalent to aa: 15.1 %), VA (equivalent to ab C ac: 50.0 %) and AA (equivalent to bb C cc C bc: 34.9 %). The cows with the V variant produced less C10:1, C12:1 and C14:1 fatty acid (FA) but more C10:0, C11:0, C14:0, C16:1 and C18:2 FA than the A variant cows (P < 0.001). Effects of c.∗1783A/G and c.∗2066T/C/G on milk fat composition were also found for the AA cows. The presence of c was associated with decreased levels of C16:1 (P < 0.001), C17:1 (P D 0.001), C18:2 cis-9, trans-13 (P D 0.045), C18:2 cis-9, trans-12 (P D 0:018) FA and C16:1 FA index (P < 0.001). The presence of b was associated with increased levels of C13:0 iso FAs (P < 0.001), monounsaturated FA (MUFA; P D 0.002) and C12:1 (P < 0.001).en
dc.publisherCopernicus Publications on behalf of the Leibniz Institute for Farm Animal Biology (FBN)en
dc.relationThe original publication is available from - Copernicus Publications on behalf of the Leibniz Institute for Farm Animal Biology (FBN) -
dc.rights© Author(s) 2020.en
dc.rightsAttribution 4.0 International*
dc.subjectdairy cattleen
dc.subjectStearoyl-CoA desaturase (SCD)en
dc.subjectfatty acidsen
dc.subjectDairy & Animal Scienceen
dc.titleVariation in the stearoyl-CoA desaturase gene (SCD) and its influence on milk fatty acid composition in late-lactation dairy cattle grazed on pastureen
dc.typeJournal Article
lu.contributor.unitLincoln Universityen
lu.contributor.unitFaculty of Agriculture and Life Sciencesen
lu.contributor.unitDepartment of Agricultural Sciencesen
dc.subject.anzsrc0702 Animal Productionen
dc.subject.anzsrc070202 Animal Growth and Developmenten
dc.subject.anzsrc070201 Animal Breedingen
dc.subject.anzsrc100104 Genetically Modified Animalsen
dc.subject.anzsrc0701 Agriculture, Land and Farm Managementen
dc.relation.isPartOfArchives Animal Breeding (AAB)en
pubs.organisational-group/LU/Agriculture and Life Sciences
pubs.organisational-group/LU/Agriculture and Life Sciences/AGSC
pubs.organisational-group/LU/Research Management Office
pubs.organisational-group/LU/Research Management Office/QE18
pubs.publication-statusPublished onlineen

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