Separation, characterisation and biological evaluation of the individual isomers of the rat selective toxicant norbormide – Isolated using a chemical derivatization strategy
Jay-Smith, M.; Wang, Z. L.; Al-Kassas, R.; Murphy, Elaine; Shapiro, Lee; Eason, Charles; Brimble, M. A.; Rennison, D.
Norbormide [5-(∝-hydroxy-∝-2-pyridylbenzyl)-7-(∝-2-pyridylbenzylidene)-5-norbornene-2,3-dicarboximide] (NRB, 1), an existing but infrequently used rodenticide, is known to be uniquely toxic to rats but relatively harmless to other rodents/mammals. However, as an acute vasoactive, NRB has a rapid onset of action, often leading to sub-lethal uptake/bait shyness. Recently, it was brought to our attention that baits containing two independently sourced batches of NRB (which differed noticeably in their stereochemical composition) displayed markedly different palatability/efficacy profiles in rats. Accordingly, with a view to independently evaluating the individual isomers of NRB in rats by means of a palatability and efficacy bait trial, this research describes the isolation of the individual isomers of endo-NRB (Y, V, W and U) from the parent mixture, by means of a chemical derivatization strategy.... [Show full abstract]
Fields of Research410202 Biosecurity science and invasive species ecology; 410407 Wildlife and habitat management; 310902 Animal cell and molecular biology
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