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dc.contributor.authorJay-Smith, M.en
dc.contributor.authorWang, Z. L.en
dc.contributor.authorAl-Kassas, R.en
dc.contributor.authorMurphy, Elaineen
dc.contributor.authorShapiro, Leeen
dc.contributor.authorEason, Charlesen
dc.contributor.authorBrimble, M. A.en
dc.contributor.authorRennison, D.en
dc.date.accessioned2021-11-19T02:02:16Z
dc.date.available2021-10-07en
dc.date.issued2021-10-07en
dc.date.submitted2021-09-29en
dc.identifier.issn1551-7004en
dc.identifier.urihttps://hdl.handle.net/10182/14423
dc.description.abstractNorbormide [5-(∝-hydroxy-∝-2-pyridylbenzyl)-7-(∝-2-pyridylbenzylidene)-5-norbornene-2,3-dicarboximide] (NRB, 1), an existing but infrequently used rodenticide, is known to be uniquely toxic to rats but relatively harmless to other rodents/mammals. However, as an acute vasoactive, NRB has a rapid onset of action, often leading to sub-lethal uptake/bait shyness. Recently, it was brought to our attention that baits containing two independently sourced batches of NRB (which differed noticeably in their stereochemical composition) displayed markedly different palatability/efficacy profiles in rats. Accordingly, with a view to independently evaluating the individual isomers of NRB in rats by means of a palatability and efficacy bait trial, this research describes the isolation of the individual isomers of endo-NRB (Y, V, W and U) from the parent mixture, by means of a chemical derivatization strategy.en
dc.format.extent40-53en
dc.languageenen
dc.language.isoenen
dc.publisherARKAT USA, Inc.en
dc.relationThe original publication is available from - ARKAT USA, Inc. - https://doi.org/10.24820/ark.5550190.p011.646en
dc.relation.urihttps://doi.org/10.24820/ark.5550190.p011.646en
dc.rights© Author(s).en
dc.rightsAttribution 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en
dc.subjectnorbormideen
dc.subjectparticle sizeen
dc.subjectrat toxicanten
dc.subjectrodenticideen
dc.subjectstereochemistryen
dc.subjectOrganic Chemistryen
dc.titleSeparation, characterisation and biological evaluation of the individual isomers of the rat selective toxicant norbormide – Isolated using a chemical derivatization strategyen
dc.typeJournal Article
lu.contributor.unitLincoln Universityen
lu.contributor.unitFaculty of Agriculture and Life Sciencesen
lu.contributor.unitDepartment of Pest Management and Conservationen
dc.identifier.doi10.24820/ark.5550190.p011.646en
dc.relation.isPartOfArkivocen
pubs.issue10en
pubs.organisational-group/LU
pubs.organisational-group/LU/Agriculture and Life Sciences
pubs.organisational-group/LU/Agriculture and Life Sciences/ECOL
pubs.organisational-group/LU/Research Management Office
pubs.organisational-group/LU/Research Management Office/QE18
pubs.publication-statusPublisheden
pubs.volume2021en
dc.identifier.eissn1551-7012en
dc.rights.licenceAttributionen
dc.subject.anzsrc2020410202 Biosecurity science and invasive species ecologyen
dc.subject.anzsrc2020410407 Wildlife and habitat managementen
dc.subject.anzsrc2020310902 Animal cell and molecular biologyen


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