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dc.contributor.authorBeasley, M.en
dc.contributor.authorFisher, P.en
dc.contributor.authorO'Connor, C.en
dc.contributor.authorEason, Charlesen
dc.date.accessioned2010-04-14T22:11:03Z
dc.date.issued2009-09en
dc.identifier.citationBeasley, M., Fisher, P., O'Connor, C., & Eason, C. (2009). Sodium fluoroacetate (1080): assessment of occupational exposures and selection of a provisional biological exposure index. New Zealand Medical Journal, 122(1302), 79-91.en
dc.identifier.issn1175-8716en
dc.identifier.urihttps://hdl.handle.net/10182/1656
dc.description.abstractAim: Sodium fluoroacetate (1080) is used for control of vertebrate pests in New Zealand. Little is known about chronic effects in humans, but animal studies demonstrate potential for adverse fetal, male fertility, and cardiac effects. We aimed to employ analyses of 1080 to help assess the degree of exposure of bait formulators and distributors, and identify specific tasks where exposure reduction appeared most indicated. We also aimed to utilise the (limited) 1080 toxicity data to assess the significance of the analytical results. Method: Exposures during various activities were assessed by monitoring air levels and blood and urine concentrations. To help evaluate the results, a provisional "biological exposure index" (BEI) was later derived, by extrapolating from experimental data. Results: Early monitoring indicated exposures were highest in relation to (cereal) bait manufacturing and aerial carrot baiting procedures. A provisional BEI of 15 μg/L for 1080 in urine was proposed. Conclusion: Further protective measures and ongoing workplace monitoring are required, particularly in the above situations. Compliance with the current BEI cannot guarantee complete safety. Any information regarding chronic adverse effects in humans, along with the associated urine levels, would assist risk assessment. Further investigation of the human kinetics of fluoroacetate would be helpful.en
dc.description.sponsorshipThis work was contracted and supported by the Animal Health Board, New Zealand.en
dc.format.extent79-91en
dc.language.isoenen
dc.publisherNew Zealand Medical Associationen
dc.relationThe original publication is available from - New Zealand Medical Associationen
dc.rightsCopyright © New Zealand Medical Associationen
dc.subject1080en
dc.subjectsodium monofluoroacetateen
dc.subjectoccupational exposureen
dc.subjectbiological exposure indexen
dc.subjecttoxicityen
dc.subjectGeneral & Internal Medicineen
dc.subject.meshHumansen
dc.subject.meshOccupational Diseasesen
dc.subject.meshFluorine Radioisotopesen
dc.subject.meshFluoroacetatesen
dc.subject.meshRodenticidesen
dc.subject.meshAir Pollutants, Occupationalen
dc.subject.meshRisk Assessmenten
dc.subject.meshThreshold Limit Valuesen
dc.subject.meshAdulten
dc.subject.meshFemaleen
dc.subject.meshMaleen
dc.titleSodium fluoroacetate (1080): assessment of occupational exposures and selection of a provisional biological exposure indexen
dc.typeJournal Article
dc.subject.marsdenFields of Research::320000 Medical and Health Sciences::320500 Pharmacology and Pharmaceutical Sciences::320504 Toxicology (incl. clinical toxicology)en
dc.subject.marsdenFields of Research::320000 Medical and Health Sciences::321200 Public Health and Health Services::321201 Environmental and occupational health and safetyen
lu.contributor.unitLincoln Universityen
lu.contributor.unitFaculty of Agriculture and Life Sciencesen
lu.contributor.unitDepartment of Pest Management and Conservationen
lu.contributor.uniten
lu.contributor.uniten
dc.subject.anzsrc11 Medical and Health Sciencesen
dc.relation.isPartOfNew Zealand Medical Journalen
pubs.issue1302en
pubs.organisational-group/LU
pubs.organisational-group/LU/Agriculture and Life Sciences
pubs.organisational-group/LU/Agriculture and Life Sciences/ECOL
pubs.organisational-group/LU/Research Management Office
pubs.organisational-group/LU/Research Management Office/2018 PBRF Staff group
pubs.publication-statusPublisheden
pubs.volume122en


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