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dc.contributor.authorFeary, James
dc.date.accessioned2011-06-27T00:02:33Z
dc.date.available2011-06-27T00:02:33Z
dc.date.issued1995
dc.identifier.urihttps://hdl.handle.net/10182/3659
dc.description.abstractThe measurement of urinary taurine and the liver specific enzymes AST and GGT in sheep with hepatic damage was undertaken to determine if urinary taurine could be used as a biomarker of hepatic damage. Two treatment groups (n = 5) were treated with O.125ml/Kg BW of carbon tetrachloride (CCl₄) (Group A), and O.125mg/Kg BW/day of sporidesmin (SPDM) (Group B) respectively. Two other treatment groups (n = 4) were used as control groups. One group was placed on a restricted diet and treated with O.625ml/Kg BW of paraffin (Group C), the other group was not dosed (Group D). Following dosing blood and urine samples were taken every 12 h for five days, before weekly sampling commenced. On day 27 animals in group A were redosed with CCl₄ , due to insignificant liver damage in this group. Blood and urine samples were again taken every 12h for 5 days, then sampling occurred weekly until the end of the trial, when all animals, except group D animals, were sacrificed. Tissue samples were then from liver, kidney, and pancreatic tissue, for metal analysis, and the livers were scored for liver damage. Liver specific enzyme activity increased in group A animals after second dosing. Enzyme activity did not increase in group B animals, even though animals' livers demonstrated fibrosis. Urinary taurine output was patchy and inconsistent with no conclusions able to be reached about this data. Results are inconclusive, with there being no indication of the effectiveness of urinary taurine as a biomarker of liver damage.en
dc.language.isoenen
dc.publisherLincoln Universityen
dc.rights.urihttps://researcharchive.lincoln.ac.nz/page/rights
dc.subjectcarbon tetrachlorideen
dc.subjectsporidesminen
dc.subjecttaurineen
dc.subjectliver specific enzymesen
dc.subjectbiomarkersen
dc.subjectliver damageen
dc.subjectsheepen
dc.titleBiomarkers in the measurement of hepatic damage in sheepen
dc.typeDissertationen
thesis.degree.grantorLincoln Universityen
thesis.degree.levelOtheren
thesis.degree.nameBachelor of Scienceen
lu.thesis.supervisorGooneratne, Ravi
lu.contributor.unitDepartment of Wine, Food and Molecular Biosciencesen
dc.rights.accessRightsDigital dissertation can be viewed by current staff and students of Lincoln University only.en
dc.subject.anzsrc070702 Veterinary Anatomy and Physiologyen
dc.subject.anzsrc0601 Biochemistry and Cell Biologyen
dc.subject.anzsrc060101 Analytical Biochemistryen


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