A model of magnesium metabolism in young sheep: transactions between plasma, cerebrospinal fluid and bone
An extension of the previously proposed model of Mg metabolism (Robson et al. 1997) has been developed to consider the transactions of Mg that are associated with cerebrospinal fluid (CSF) and bone. The representation of the CSF as a single Mg compartment with uptake from the plasma described by Michaelis–Menten kinetics gives very good agreement with published experiments. Analysis of the available information on resorption of Mg from adult bone indicates that this process makes a negligible contribution to Mg homeostasis and can be omitted from the model.
Keywordssheep; magnesium; mathematical modelling; hypomagnesaemia; grass tetany; simulation; Nutrition & Dietetics; Bone and Bones; Animals; Bone Resorption; Calcium; Metabolic Clearance Rate; Models, Animal; Biological Transport; Homeostasis; Models, Biological
Copyright © The Authors 2004