Motor Neurone Disease (MND) is a progressive disease and once the symptoms are
jointly evident enough to allow diagnosis, MND is a rapidly terminal disease. A plausible
mechanism is the enhanced Apoptosis of the Motor Neurones leading to the loss of
skeletal muscular control and strength. This has led to the development of a hypothesis
that attempts to explain the overall evidence pattern, including the seasonal MND
related birth peak in Spring, the familial and occupational MND associations. The
hypothesis proposes that the development of MND is based on a variable initial volume
of Motor Neurons and the development of the disease through the enhanced cumulative
Apoptosis rates over people’s life-time, leading to premature loss of the Motor Neuron
muscular control and premature death primarily through lung failure. The cumulative
life-time damage from exposure to environmental neurotoxins, stressful activity that
reduces sleep quality and melatonin, heavy work load periods, antioxidant levels in
diets, are a complex set of factors that can enhance the Motor Neurone Apoptosis rate.
This is connected to the lack of CNS neuron regeneration. The associated
environmental neurotoxin effects include those from heavy metals, smoking, agricultural
chemicals, water and air pollution toxic chemicals and genotoxic electromagnetic fields.
The ubiquitous nature of any associated substance, especially dioxin and
electromagnetic fields, suggests that they are the largest general population risk factor.
Electromagnetic fields and some toxic chemicals have been found to pass cancer on to
children from mother and/or father’s exposures. This supports a genotoxic mechanism
that is supported by many studies showing chromosome damage and DNA strand
breakage. These disease agents are likely to reduce the initial Motor Neuron Volume
and/or advance the rate of development of Motor Neuron Disease through enhanced
Apoptosis rates. Reducing the general population's exposure to environmental and
residential genotoxic and neurotoxic substances is likely to be associated with a
significant reduction in the incidence of MND in future generations.[Show full abstract]
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