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Variation in the Yak calpastatin gene (CAST)

dc.contributor.authorYang, G.en
dc.contributor.authorZhou, Huitongen
dc.contributor.authorHu, J.en
dc.contributor.authorLuo, Y.en
dc.contributor.authorHickford, Jonathan G. H.en
dc.date.accessioned2015-06-04T04:09:59Z
dc.date.issued2012en
dc.identifier.citationYang G., Zhou H., Hu J., Luo Y. & Hickford, J.G.H. (2012). Variation in the yak calpastatin gene (CAST). International Journal of Genetics, 4(1) pp.-72-73.en
dc.identifier.issn0975-2862en
dc.identifier.urihttps://hdl.handle.net/10182/6581
dc.description.abstractCalpastatin (CAST) is a specific inhibitor of calpain (calcium-dependent cysteine protease). This study investigated the potential for variation in yak (Bos grennies) CAST. PCR-SSCP analysis of exon 6 of yak CAST revealed three unique patterns (named A-C). Sequencing of the amplicons revealed two nucleotide substitutions. One substitution (c.398G/C) would nominally change the amino acid sequence (p.S133T) of yak calpastatin. The variant sequence A which carried c.398C was the most common in the yaks tested (95.1%). This is the first report that found yak CAST is variable, and as in pigs, sheep and cattle, this variation may affect animal production traits.en
dc.format.extent72-73en
dc.language.isoenen
dc.publisherBioinfo Publicationsen
dc.relationThe original publication is available from - Bioinfo Publications - http://www.bioinfo.in/uploadfiles/13330165644_1_1_IJG.pdfen
dc.rightsCopyright©2012 Yang G., et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.en
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en
dc.subjectCASTen
dc.subjectgenetic variationen
dc.subjectYak (Bos grennies)en
dc.subjectPCR- single strand conformational polymorphism (PCR-SSCP)en
dc.titleVariation in the Yak calpastatin gene (CAST)en
dc.typeJournal Article
lu.contributor.unitLincoln Universityen
lu.contributor.unitFaculty of Agriculture and Life Sciencesen
lu.contributor.unitDepartment of Agricultural Sciencesen
dc.subject.anzsrc0604 Geneticsen
dc.subject.anzsrc060602 Animal Physiology - Cellen
dc.relation.isPartOfInternational Journal of Geneticsen
pubs.issue1en
pubs.organisational-group/LU
pubs.organisational-group/LU/Agriculture and Life Sciences
pubs.organisational-group/LU/Agriculture and Life Sciences/AGSC
pubs.organisational-group/LU/Research Management Office
pubs.organisational-group/LU/Research Management Office/QE18
pubs.publication-statusPublisheden
pubs.publisher-urlhttp://www.bioinfo.in/uploadfiles/13330165644_1_1_IJG.pdfen
pubs.volume4en
dc.publisher.placeUSAen
dc.identifier.eissn0975-9158en
dc.rights.licenceAttributionen
lu.identifier.orcid0000-0001-9313-761X
lu.identifier.orcid0000-0001-7620-3160


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