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dc.contributor.authorZhou, Huitongen
dc.contributor.authorCheng, Paulen
dc.contributor.authorAzimu, W.en
dc.contributor.authorHodge, Simonen
dc.contributor.authorEdwards, Granten
dc.contributor.authorHickford, Jonathan G. H.en
dc.identifier.citationZhou, H., Cheng, L., Azimu, W., Hodge, S., Edwards, G. R., & Hickford, J. G. H. (2015). Variation in the bovine FABP4 gene affects milk yield and milk protein content in dairy cows. Scientific Reports, 5. doi:10.1038/srep10023en
dc.description.abstractFatty acid binding proteins (FABPs) bind long-chain fatty acids and are involved in their intracellular transport. Of the known bovine FABP genes, FABP₄ has been mapped to a region on chromosome 14 that contains quantitative trait loci for milk traits. This study investigated the association of FABP₄ haplotypes with milk production traits in 719 Holstein-Friesian × Jersey cows. Polymerase chain reaction-single strand conformational polymorphism (PCR-SSCP) analysis of a variable region of the gene revealed three haplotypes (A, B and C). Five single nucleotide polymorphisms (SNPs) were identified: two in exon 3 and three in intron 3. A was associated (P = 0.032) with increased milk protein percentage (present: 4.00 ± 0.02%; absent: 3.95 ± 0.02%) and B was associated (P = 0.009) with increased milk yield (present: 23.81 ± 0.23 kg/d; absent: 23.06 ± 0.21 kg/d), but tended to be associated with a decrease in protein percentage and an increase in protein yield. Cows with genotypes AA, AB and AC produced less milk, but with a higher protein percentage than BC cows. This suggest that FABP₄ affects milk yield and milk protein content, both economically important traits, and that further study of this gene is warranted.en
dc.publisherScientific Reportsen
dc.relationThe original publication is available from - Scientific Reports -
dc.rightsCopyright © The Authors. This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit
dc.subjectFatty acid binding proteinsen
dc.subjectPolymerase chain reaction-single strand conformational polymorphisen
dc.subjectmilk proteinen
dc.subject.meshChromosomes, Mammalianen
dc.subject.meshMilk Proteinsen
dc.subject.meshQuantitative Trait, Heritableen
dc.subject.meshPolymorphism, Single-Stranded Conformationalen
dc.subject.meshPolymorphism, Single Nucleotideen
dc.subject.meshFatty Acid-Binding Proteinsen
dc.titleVariation in the bovine FABP₄ gene affects milk yield and milk protein content in dairy cowsen
dc.typeJournal Article
lu.contributor.unitLincoln Universityen
lu.contributor.unitFaculty of Agriculture and Life Sciencesen
lu.contributor.unitDepartment of Agricultural Sciencesen
lu.contributor.unitVice Chancellor's Officeen
dc.subject.anzsrc0604 Geneticsen
dc.subject.anzsrc0702 Animal Productionen
dc.relation.isPartOfScientific Reportsen
pubs.notesArticle number 10023en
pubs.organisational-group/LU/Agriculture and Life Sciences
pubs.organisational-group/LU/Agriculture and Life Sciences/AGSC
pubs.organisational-group/LU/Research Management Office
pubs.organisational-group/LU/Research Management Office/QE18
pubs.organisational-group/LU/Vice Chancellor's Office

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