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dc.contributor.authorYang, G.
dc.contributor.authorZhou, Huitong
dc.contributor.authorForrest, R. H.
dc.contributor.authorFang, Qian
dc.contributor.authorLuo, Y.
dc.contributor.authorHickford, Jonathan G. H.
dc.date.accessioned2016-11-07T22:12:33Z
dc.date.available2013-05-08en
dc.date.issued2013-08
dc.date.submitted2013-04-29en
dc.identifier.citationYang, G.; Zhou, H.; Forrest, R. H.; Fang, Q.; Luo, Y.; Hickford, J. G. H. (2013). Halplotypes of the ovine ADRB3 gene (ADRB3) and their association with post-weaning growth in New Zealand Suffolk sheep. Molecular Biology Reports, 40(8), 4805-4810. doi:10.1007/s11033-013-2576-5
dc.identifier.issn0301-4851en
dc.identifier.urihttps://hdl.handle.net/10182/7563
dc.description.abstractThe β3-adrenergic receptor (ADRB3) regulates thermogenesis and lipolysis in brown and white adipose tissue. Previously, sixteen ovine ADRB3 haplotypes have been defined. In this study, the relationship between these ADRB3 haplotypes and variation in post-weaning growth was investigated in 797 New Zealand Suffolk lambs from 38 sire lines and eight studs, using PCR-SSCP and General Linear Mixed-effects Models. Seven haplotypes were found in these sheep and they comprised five previously reported intron sequences and four previously reported 3′UT sequences. The frequencies of the various diplotypes ranged from 0.1 to 17.6 % and individual haplotypes from 0.8 to 32.5 %. The presence of haplotype A-b was associated with a decreased weaning-weight (P = 0.001). Sheep with the B-c/F-e diplotype had a higher mean weaning-weight than those with A-b/B-c or A-b/E-e (P < 0.05). The presence of C-a was found to be associated with increased post-weaning growth (P = 0.008), while the presence of B-c was associated with decreased post-weaning growth (P = 0.005). Sheep with A-b/C-a had higher mean post-weaning growth than those with A-b/A-b, A-b/B-c, B-c/B-c, B-c/E-e or B-c/F-e (P < 0.05). Sheep with B-c/B-c had lower mean post-weaning growth than those with A-b/C-a or B-c/C-a (P < 0.05). Additive effects for the different forms of the B-c haplotypes on post-weaning growth were identified. The effects of the ovine ADRB3 haplotypes on weaning-weight and post-weaning growth confirm that they could be used as a candidate gene-marker for improving sheep growth. © 2013 Springer Science+Business Media Dordrecht.en
dc.format.extent4805-4810en
dc.language.isoen
dc.publisherSpringer Netherlands
dc.relationThe original publication is available from - Springer Netherlands - https://doi.org/10.1007/s11033-013-2576-5 - http://link.springer.com/article/10.1007/s11033-013-2576-5#enumerationen
dc.relation.urihttps://doi.org/10.1007/s11033-013-2576-5en
dc.rights© 2013 Springer Science+Business Media Dordrecht.
dc.subjectADRB3en
dc.subjectPCR-SSCPen
dc.subjectNZ Suffolk sheepen
dc.subjectAssociationen
dc.subjectPolymorphismen
dc.subjectHaplotypeen
dc.subjectBiochemistry & Molecular Biologyen
dc.subject.meshAnimalsen
dc.subject.meshSheepen
dc.subject.meshBody Weighten
dc.subject.meshReceptors, Adrenergic, beta-3en
dc.subject.meshLinear Modelsen
dc.subject.meshPolymerase Chain Reactionen
dc.subject.meshBreedingen
dc.subject.meshWeaningen
dc.subject.meshHaplotypesen
dc.subject.meshPhenotypeen
dc.subject.meshPolymorphism, Single-Stranded Conformationalen
dc.subject.meshNew Zealanden
dc.titleHalplotypes of the ovine ADRB3 gene (ADRB3) and their association with post-weaning growth in New Zealand Suffolk sheepen
dc.typeJournal Article
lu.contributor.unitLincoln University
lu.contributor.unitFaculty of Agriculture and Life Sciences
lu.contributor.unitDepartment of Agricultural Sciences
dc.identifier.doi10.1007/s11033-013-2576-5en
dc.relation.isPartOfMolecular Biology Reportsen
pubs.issue8en
pubs.organisational-group/LU
pubs.organisational-group/LU/Agriculture and Life Sciences
pubs.organisational-group/LU/Agriculture and Life Sciences/AGSC
pubs.organisational-group/LU/Research Management Office
pubs.organisational-group/LU/Research Management Office/QE18
pubs.publication-statusPublisheden
pubs.publisher-urlhttp://link.springer.com/article/10.1007/s11033-013-2576-5#enumerationen
pubs.volume40en
dc.identifier.eissn1573-4978en
lu.identifier.orcid0000-0001-9313-761X
lu.identifier.orcid0000-0001-7620-3160


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