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dc.contributor.authorKeenan, Jacqueline I.
dc.date.accessioned2016-11-13T22:18:58Z
dc.date.available2016-11-13T22:18:58Z
dc.date.issued1992
dc.identifier.urihttps://hdl.handle.net/10182/7576
dc.description.abstractToxocara canis (T. canis) is the common roundworm of dogs and other Canidae. Seroprevalence surveys suggest that human infection with this parasite is second only the pinworm in developed countries. Human infection with T. canis is difficult to demonstrate because infecting larvae remain developmentally arrested within the tissues. The current diagnosis of toxocariasis is based on clinical findings correlated with the detection of specific antibodies in the serum. However, many seroresponders show no evidence of clinical infection which questions the relevance of detecting an antibody response to T. canis in these people. T. canis larvae are known to release excretory-secretory antigens in vivo and in vitro. The detection of these antigens in serum potentially provides a marker for current infection. The aim of this research was the development and evaluation of an ELISA capable of detecting circulating ED antigens in human serum. Four assays for ES antigen detection were evaluated using both polyclonal antisera produced against T. canis and a T. canis-specific monoclonal antibody.en
dc.language.isoenen
dc.publisherLincoln Universityen
dc.rights.urihttps://researcharchive.lincoln.ac.nz/page/rights
dc.subjectToxocara canisen
dc.subjectexcretory/secretory antigensen
dc.subjectEnzyme-Linked Immunosorbent Assay (ELISA)en
dc.subjectHumansen
dc.subjectdiagnostic assayen
dc.subjectinfectionen
dc.subjectparasitic infectionen
dc.subjectroundwormen
dc.titleEvaluation of diagnostic assays for Toxocara canis infection in humansen
dc.typeThesisen
thesis.degree.grantorLincoln Universityen
thesis.degree.levelMastersen
thesis.degree.nameMaster of Applied Scienceen
lu.thesis.supervisorHickford, Jon
lu.contributor.unitDepartment of Wine, Food and Molecular Biosciencesen
dc.subject.anzsrc110803 Medical Parasitologyen
dc.subject.anzsrc110705 Humoural Immunology and Immunochemistryen


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