Oral delivery of lactoferrin: a review

Yao, X; Bunt, Craig; Cornish, J; Quek, S-Y; Wen, J

Item

Oral delivery of lactoferrin: a review

Yao, X
;
Bunt, Craig
;
Cornish, J
;
Quek, S-Y
;
Wen, J

Date

2013-06

Type

Journal Article

Collections

Metadata-only (no full-text)

Keywords

lactoferrin (Lf), gastrointestinal tract (GIT), PEGylation, chitosan, nanoparticles, liposomes

Fields of Research

ANZSRC::110106 Medical Biochemistry: Proteins and Peptides (incl. Medical Proteomics) , ANZSRC::111502 Clinical Pharmacology and Therapeutics , ANZSRC::3101 Biochemistry and cell biology , ANZSRC::3205 Medical biochemistry and metabolomics , ANZSRC::3404 Medicinal and biomolecular chemistry

Abstract

Lactoferrin (Lf), as a therapeutic protein drug, has attracted much interest due to its many important roles in human and animal health and development. Oral delivery offers the most convenient way for supplementing Lf. However, the bioavailability of orally administered Lf is limited by a number of barriers associated with protein absorption. During the past decade, several oral delivery systems have been developed to preserve Lf stability in order to enhance gastric residence time and improve its bioavailability. This review summarizes various pharmaceutical strategies currently under investigation including: PEGylation, absorption enhancers, enzymatic inhibitors and advanced drug carrier systems.

Oral delivery of lactoferrin: a review

Yao, X
;
Bunt, Craig
;
Cornish, J
;
Quek, S-Y
;
Wen, J

Date

Type

Collections

Keywords

Fields of Research

Abstract

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