Priestia megaterium ASC-1 Isolated from pickled cabbage ameliorates hyperuricemia by degrading uric acid in rats
Date
2024-04
Type
Journal Article
Fields of Research
ANZSRC::310605 Industrial microbiology (incl. biofeedstocks), ANZSRC::321002 Food properties (incl. characteristics and health benefits), ANZSRC::420306 Health care administration, ANZSRC::310103 Cell metabolism, ANZSRC::320601 Gene and molecular therapy, ANZSRC::3107 Microbiology, ANZSRC::3207 Medical microbiology
Abstract
Pickled cabbage, a traditional fermented food rich in functional microorganisms, can effectively control hyperuricemia and gout. In this study, a Priestia megaterium ASC-1 strain with strong uric acid (UA) degradation ability was isolated from pickled cabbage. After oral administration for 15 days, ASC-1 was stably colonized in the rats in this study. ASC-1 significantly reduced UA levels (67.24%) in hyperuricemic rats. Additionally, ASC-1 alleviated hyperuricemia-related inflammatory response, oxidative stress, and blood urea nitrogen. Intestinal microbial diversity results showed that ASC-1 restored intestinal injury and gut flora dysbiosis caused by hyperuricemia. These findings suggest that P. megaterium ASC-1 may be used as a therapeutic adjuvant for the treatment of hyperuricemia.
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© 2024 by the authors. Licensee MDPI, Basel, Switzerland.
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