Wannige, CKulasiri, DonSamarasinghe, Sandhya2015-04-192013-10-042014-01-212013-09-20Wannige, C. T., Kulasiri, D. & Samarasinghe, S. (2014). A nutrient dependant switch explains mutually exclusive existence of meiosis and mitosis initiation in budding yeast. ournal of Theoretical Biology, https://doi.org/10.1016/j.jtbi.2013.09.0300022-519324099720 (pubmed)https://hdl.handle.net/10182/6529Nutrients from living environment are vital for the survival and growth of any organism. Budding yeast diploid cells decide to grow by mitosis type cell division or decide to create unique, stress resistant spores by meiosis type cell division depending on the available nutrient conditions. To gain a molecular systems level understanding of the nutrient dependant switching between meiosis and mitosis initiation in diploid cells of budding yeast, we develop a theoretical model based on ordinary differential equations (ODEs) including the mitosis initiator and its relations to budding yeast meiosis initiation network. Our model accurately and qualitatively predicts the experimentally revealed temporal variations of related proteins under different nutrient conditions as well as the diverse mutant studies related to meiosis and mitosis initiation. Using this model, we show how the meiosis and mitosis initiators form an all-or-none type bistable switch in response to available nutrient level (mainly nitrogen). The transitions to and from meiosis or mitosis initiation states occur via saddle node bifurcation. This bidirectional switch helps the optimal usage of available nutrients and explains the mutually exclusive existence of meiosis and mitosis pathways.pp.88-101Print-ElectronicenCopyright © 2014, Elsevier Ltd. All rights reserved.bistable switchingnegative-feedbackbifurcationSaccharomyces cerevisiaeSaccharomycetalesSaccharomyces cerevisiaeMeiosisMitosisAlgorithmsModels, BiologicalNutritional Physiological PhenomenaStress, PhysiologicalFeedback, PhysiologicalJournal Article10.1016/j.jtbi.2013.09.0301095-8541ANZSRC::31 Biological sciencesANZSRC::49 Mathematical sciences