Wang, Guan,Zhou, HuitongGong, HHe, Jianning,Luo, Yuzhu,Hickford, JonathanHu, Jiang,Wang, Jiqing,Liu, Xiu,Li, Shaobin,2020-05-252020-02-032020-02-032020-01-302076-2615KW7IE (isidoc)32028610 (pubmed)https://hdl.handle.net/10182/11921Lipin 1 plays an important role in lipid metabolism. In this study; we searched for variation in the ovine lipin 1 gene (LPIN1) in three gene regions (a 5′ non-coding region; a region containing an alternatively spliced exon in intron 4; and a region containing coding exon 6) using polymerase chain reaction-single strand conformation polymorphism (PCR-SSCP) analysis. The greatest amount of alleles was found in coding exon 6; with five sequences being detected. The effect of variation in this exon was investigated in 242 New Zealand Romney lambs derived from 12 sire-lines. The presence of variant E₃ was associated with a decrease in birth weight (p = 0.005) and the proportion of leg yield (p = 0.045), but with an increase in hot carcass weight (p = 0.032) and the proportion of loin yield (p = 0.014). The presence of variant B₃ was associated with an increased pre-weaning growth rate (p = 0.041), whereas the presence of variant C₃ was associated with an increase in shoulder yield (p < 0.001). These results suggest that ovine LPIN1 variation may have value as a genetic marker for improving meat production and carcass traits.9 pagesElectronicen© 2020 by the authorslipin 1 gene (LPIN1)nucleotide variationPCR-SSCPbirth weightmeat yieldJournal Article10.3390/ani10020237ANZSRC::0702 Animal ProductionANZSRC::0604 GeneticsANZSRC::0601 Biochemistry and Cell Biology2076-2615ANZSRC::3003 Animal productionANZSRC::3009 Veterinary sciencesANZSRC::3109 Zoologyhttps://creativecommons.org/licenses/by/4.0/Attribution