Debi, PBarua, HAhmmed, MirjaBhowmik, S2025-07-312025-07-302025-07-312025-07-302025-07-291660-3397https://hdl.handle.net/10182/19295The popularity of bioactive compounds extracted from sea cucumbers is growing due to their wide application in the pharmaceutical industry, particularly in the development of drugs for neurological disorders. Different types of compounds, such as saponins, phenolic compounds, cerebrosides, and glucocerebrosides, are being studied intensively for their efficacy in assessing the treatment of neurodegenerative diseases, including Alzheimer’s disease, Parkinson’s disease, and brain tumors, among others. Positive results have been observed in the upregulation in the content of p-CREB, p-PL3K, BDNF, SOD, and MDA. Furthermore, the neuroprotective mechanism of the compounds against Alzheimer’s disease revealed that suppressing the phosphorylation of tau protein by the PI3K/Akt/GSK3β pathway leads to improved synaptic plasticity and reduced nerve fiber tangles. This comprehensive review explores recent findings on the therapeutic potential of sea cucumber bioactives in the treatment of brain-related disorders.47 pagesen© The Authors. Published by MDPI.Alzheimer’s diseaseglucocerebrosidesParkinson’s diseasebrain healthseafood bioactivePI3K/Akt/GSK3β pathwaysaponinphenolic compoundscerebrosidesJournal Article10.3390/md230803101660-3397ANZSRC::3214 Pharmacology and pharmaceutical sciencesANZSRC::3406 Physical chemistryhttps://creativecommons.org/licenses/by/4.0/Attribution