He, YKulasiri, DonSamarasinghe, Sandhya2017-07-242014-06-122014-082014-06-06He, Y., Kulasiri, D., Samarasinghe, S. (2014). Systems biology of synaptic plasticity: a review on N-methyl-D-aspartate receptor mediated biochemical pathways and related mathematical models. BioSystems, 122, 7-18. doi:10.1016/j.biosystems.2014.06.0050303-264724929130 (pubmed)https://hdl.handle.net/10182/8350Synaptic plasticity, an emergent property of synaptic networks, has shown strong correlation to one of the essential functions of the brain, memory formation. Through understanding synaptic plasticity, we hope to discover the modulators and mechanisms that trigger memory formation. In this paper, we first review the well understood modulators and mechanisms underlying N-methyl-D-aspartate receptor dependent synaptic plasticity, a major form of synaptic plasticity in hippocampus, and then comment on the key mathematical modelling approaches available in the literature to understand synaptic plasticity as the integration of the established functionalities of synaptic components.pp.7-18Print-Electronicen© 2014 Elsevier Ireland Ltd. All rights reserved.synaptic plasticitysystems biologymemory formationLTPLTDBrainHumansCalciumCalmodulinReceptors, GlutamateReceptors, N-Methyl-D-AspartateMemorySystems BiologySignal TransductionNeuronal PlasticityModels, BiologicalJournal Article10.1016/j.biosystems.2014.06.005ANZSRC::0601 Biochemistry and Cell BiologyANZSRC::110199 Medical Biochemistry and Metabolomics not elsewhere classified1872-8324ANZSRC::31 Biological sciencesANZSRC::40 Engineering