Weld, RJPlummer, KMCarpenter, MARidgway, HJ2020-02-262006-01-162006-01-161001-060216467874 (pubmed)https://hdl.handle.net/10182/11477The study of gene function in filamentous fungi is a field of research that has made great advances in very recent years. A number of transformation and gene manipulation strategies have been developed and applied to a diverse and rapidly expanding list of economically important filamentous fungi and oomycetes. With the significant number of fungal genomes now sequenced or being sequenced, functional genomics promises to uncover a great deal of new information in coming years. This review discusses recent advances that have been made in examining gene function in filamentous fungi and describes the advantages and limitations of the different approaches.pp.31-44Printen© 2006 IBCB, SIBS, CASfunctional genomicsgene replacementfilamentous fungihomologous recombinationRNAigene silencingoomycetesFungiSaccharomyces cerevisiaeDNA, BacterialDNA Transposable ElementsGenetic MarkersOligonucleotide Array Sequence AnalysisGenetic TechniquesCloning, MolecularGene Expression ProfilingMutagenesis, InsertionalProteomicsGenomicsGene Expression Regulation, FungalRNA InterferenceTransformation, GeneticGenome, FungalEnhancer Elements, GeneticPromoter Regions, GeneticJournal Article10.1038/sj.cr.73100061748-7838ANZSRC::3101 Biochemistry and cell biology