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Investigation of variation in the promoter region of the myostatin gene (GDF-8) in New Zealand cattle

Authors
Rasmussen, Katianna Louisa
Date
2016
Type
Dissertation
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Dissertations
Department of Agricultural Sciences
Keywords
bovine, double-muscling, myostatin gene (MSTN), Promoter Regions, Genetic, GDF8, PCR- single strand conformational polymorphism (PCR-SSCP), cattle
Fields of Research
ANZSRC::060103 Cell Development, Proliferation and Death, ANZSRC::0601 Biochemistry and Cell Biology, ANZSRC::070202 Animal Growth and Development, ANZSRC::070201 Animal Breeding
Abstract
Myostatin, also called growth and differentiation factor 8 (GDF-8), has the specific function of negatively regulating muscle growth and muscle homeostasis through its interactions with myoblasts during their proliferation to myotubes. As a result, the absence of functional myostatin proteins causes an increase in whole-body muscling. In this study a section of the promoter region of the bovine myostatin gene (GDF-8) was analysed to determine whether variation is present. Belgian Blue, South Devon and KiwiCrossTM cattle were analysed. The DNA sequence proved uniform across all animals, therefore all carry the same genotype and polymorphisms are not present.
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Name: Rasmussen_BSc(Hons).pdf
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https://hdl.handle.net/10182/7308
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