Variation in the Yak calpastatin gene (CAST)
Variation in the Yak calpastatin gene (CAST)
Yang, G. Zhou, Huitong Hu, J. Luo, Y. Hickford, Jonathan G. H.
Yang, G.
Zhou, Huitong
Hu, J.
Luo, Y.
Hickford, Jonathan G. H.
Date
2012
Type
Journal Article
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ANZSRC::0604 Genetics , ANZSRC::060602 Animal Physiology - Cell
Abstract
Calpastatin (CAST) is a specific inhibitor of calpain (calcium-dependent cysteine protease). This study investigated the potential
for variation in yak (Bos grennies) CAST. PCR-SSCP analysis of exon 6 of yak CAST revealed three unique patterns (named A-C). Sequencing
of the amplicons revealed two nucleotide substitutions. One substitution (c.398G/C) would nominally change the amino acid sequence
(p.S133T) of yak calpastatin. The variant sequence A which carried c.398C was the most common in the yaks tested (95.1%). This
is the first report that found yak CAST is variable, and as in pigs, sheep and cattle, this variation may affect animal production traits.
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Copyright©2012 Yang G., et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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