Does cortisol mediate endotoxin-induced inhibition of pulsatile luteinizing hormone and gonadotropin-releasing hormone secretion?
dc.contributor.author | Debus, N | |
dc.contributor.author | Breen, KM | |
dc.contributor.author | Barrell, GK | |
dc.contributor.author | Billings, HJ | |
dc.contributor.author | Brown, M | |
dc.contributor.author | Young, EA | |
dc.contributor.author | Karsch, FJ | |
dc.coverage.spatial | United States | |
dc.date.accessioned | 2010-04-25T23:36:09Z | |
dc.date.issued | 2002-10 | |
dc.description.abstract | Bacterial endotoxin (lipopolysaccharide), a commonly used model of immune/inflammatory stress, inhibits reproductive neuroendocrine activity and concurrently induces a profound stimulation of the hypothalamo-pituitary-adrenal axis. We employed two approaches to test the hypothesis that enhanced secretion of cortisol mediates endotoxin-induced suppression of pulsatile GnRH and LH secretion in the ovariectomized ewe. First, we mimicked the endotoxin-induced increase in circulating cortisol by delivering the glucocorticoid in the absence of the endotoxin challenge. Within 1–2 h, experimentally produced increments in circulating cortisol suppressed pulsatile LH secretion in a dose-dependent fashion. Second, we blocked the endotoxin-induced stimulation of cortisol secretion using the drug metyrapone, which inhibits the 11-β hydroxylase enzyme necessary for cortisol biosynthesis. In the absence of a marked stimulation of cortisol secretion, endotoxin still profoundly inhibited pulsatile GnRH and LH secretion. We conclude that, although enhanced cortisol secretion may contribute to endotoxin-induced suppression of reproductive neuroendocrine activity, the marked stimulation of the glucocorticoid is not necessary for this response. Our findings are consistent with the hypothesis that immune/inflammatory stress inhibits reproductive neuroendocrine activity via more than one inhibitory pathway, one involving enhanced secretion of cortisol and the other(s) being independent of this glucocorticoid. | |
dc.format.extent | pp.3748-3758 | |
dc.format.medium | ||
dc.identifier | https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=elements_prod&SrcAuth=WosAPI&KeyUT=WOS:000178212800006&DestLinkType=FullRecord&DestApp=WOS_CPL | |
dc.identifier.citation | Debus, N., Breen, K. M., Barrell, G. K., Billings, H. J., Brown, M., Young, E. A., et al. (2002). Does cortisol mediate endotoxin-induced inhibition of pulsatile luteinizing hormone and gonadotropin-releasing hormone secretion? Endocrinology, 143(10), 3748-3758. | |
dc.identifier.doi | 10.1210/en.2002-220291 | |
dc.identifier.eissn | 1945-7170 | |
dc.identifier.issn | 0013-7227 | |
dc.identifier.other | 12239084 (pubmed) | |
dc.identifier.uri | https://hdl.handle.net/10182/1740 | |
dc.language.iso | en | |
dc.publisher | Endocrine Society | |
dc.relation | The original publication is available from Endocrine Society - https://doi.org/10.1210/en.2002-220291 - http://dx.doi.org/10.1210/en.2002-220291 | |
dc.relation.isPartOf | Endocrinology | |
dc.relation.uri | https://doi.org/10.1210/en.2002-220291 | |
dc.rights | Copyright © 2002 by The Endocrine Society | |
dc.subject | cortisol | |
dc.subject | bacterial endotoxin | |
dc.subject | luteinizing hormone | |
dc.subject | gonadotropin-releasing hormone | |
dc.subject | neuroendocrinology | |
dc.subject.anzsrc2020 | ANZSRC::3202 Clinical sciences | |
dc.subject.marsden | Marsden::321004 Endocrinology | |
dc.subject.mesh | Pituitary Gland | |
dc.subject.mesh | Animals | |
dc.subject.mesh | Sheep | |
dc.subject.mesh | Metyrapone | |
dc.subject.mesh | Hydrocortisone | |
dc.subject.mesh | Progesterone | |
dc.subject.mesh | Luteinizing Hormone | |
dc.subject.mesh | Endotoxins | |
dc.subject.mesh | Drug Combinations | |
dc.subject.mesh | Pulsatile Flow | |
dc.subject.mesh | Female | |
dc.subject.mesh | Gonadotropin-Releasing Hormone | |
dc.title | Does cortisol mediate endotoxin-induced inhibition of pulsatile luteinizing hormone and gonadotropin-releasing hormone secretion? | |
dc.type | Journal Article | |
lu.contributor.unit | LU | |
lu.contributor.unit | LU|Agriculture and Life Sciences | |
lu.contributor.unit | LU|Agriculture and Life Sciences|AGSC | |
lu.contributor.unit | LU|Research Management Office | |
lu.contributor.unit | LU|Research Management Office|OLD QE18 | |
lu.identifier.orcid | 0000-0001-7644-6816 | |
pubs.issue | 10 | |
pubs.publication-status | Published | |
pubs.publisher-url | http://dx.doi.org/10.1210/en.2002-220291 | |
pubs.volume | 143 |
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