Therapeutic potential of sea cucumber-derived bioactives in the prevention and management of brain-related disorders: a comprehensive review

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dc.contributor.authorDebi, P
dc.contributor.authorBarua, H
dc.contributor.authorAhmmed, Mirja
dc.contributor.authorBhowmik, S
dc.date.accessioned2025-07-31T04:11:40Z
dc.date.available2025-07-30
dc.date.available2025-07-31T04:11:40Z
dc.date.issued2025-07-30
dc.date.submitted2025-07-29
dc.description.abstractThe popularity of bioactive compounds extracted from sea cucumbers is growing due to their wide application in the pharmaceutical industry, particularly in the development of drugs for neurological disorders. Different types of compounds, such as saponins, phenolic compounds, cerebrosides, and glucocerebrosides, are being studied intensively for their efficacy in assessing the treatment of neurodegenerative diseases, including Alzheimer’s disease, Parkinson’s disease, and brain tumors, among others. Positive results have been observed in the upregulation in the content of p-CREB, p-PL3K, BDNF, SOD, and MDA. Furthermore, the neuroprotective mechanism of the compounds against Alzheimer’s disease revealed that suppressing the phosphorylation of tau protein by the PI3K/Akt/GSK3β pathway leads to improved synaptic plasticity and reduced nerve fiber tangles. This comprehensive review explores recent findings on the therapeutic potential of sea cucumber bioactives in the treatment of brain-related disorders.
dc.format.extent47 pages
dc.identifier.doi10.3390/md23080310
dc.identifier.eissn1660-3397
dc.identifier.issn1660-3397
dc.identifier.urihttps://hdl.handle.net/10182/19295
dc.language.isoen
dc.publisherMultidisciplinary Digital Publishing Institute (MDPI)
dc.relationThe original publication is available from Multidisciplinary Digital Publishing Institute (MDPI) - https://doi.org/10.3390/md23080310 - https://doi.org/10.3390/md23080310
dc.relation.ispartofMarine Drugs
dc.relation.urihttps://doi.org/10.3390/md23080310
dc.rights© The Authors. Published by MDPI.
dc.rights.ccnameAttribution
dc.rights.ccurihttps://creativecommons.org/licenses/by/4.0/
dc.subjectAlzheimer’s disease
dc.subjectglucocerebrosides
dc.subjectParkinson’s disease
dc.subjectbrain health
dc.subjectseafood bioactive
dc.subjectPI3K/Akt/GSK3β pathway
dc.subjectsaponin
dc.subjectphenolic compounds
dc.subjectcerebrosides
dc.subject.anzsrc2020ANZSRC::3214 Pharmacology and pharmaceutical sciences
dc.subject.anzsrc2020ANZSRC::3406 Physical chemistry
dc.titleTherapeutic potential of sea cucumber-derived bioactives in the prevention and management of brain-related disorders: a comprehensive review
dc.typeJournal Article
lu.contributor.unitLincoln University
lu.contributor.unitFaculty of Agriculture and Life Sciences
lu.contributor.unitDepartment of Wine, Food and Molecular Biosciences
lu.identifier.orcid0000-0003-4467-0615
pubs.article-number310
pubs.issue8
pubs.publication-statusPublished
pubs.publisher-urlhttps://doi.org/10.3390/md23080310
pubs.volume23
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