Do functional keratin dressings accelerate epithelialization in human partial thickness wounds? A randomized controlled trial on skin graft donor sites
dc.contributor.author | Davidson, A. | |
dc.contributor.author | Jina, N. H. | |
dc.contributor.author | Marsh, Clive | |
dc.contributor.author | Than, M. | |
dc.contributor.author | Simcock, J. | |
dc.date.accessioned | 2018-01-24T04:54:08Z | |
dc.date.issued | 2013-08-29 | |
dc.description.abstract | Objective: To determine if the experimental (keratin-based) dressing accelerates epithelialization rates during healing of partial-thickness wounds, relative to a Standard Care dressing. Method: A randomized control trial was conducted using a Standard Care dressing side by side with the experimental dressing on a sample (n=26) of partial-thickness donor site wounds. The proximal/distal placement of the control and treatment was randomized. Percentage epithelialization after approximately 7 days was estimated from which time to fully epithelialize can be inferred. Patients were grouped into “young” (≤50 y/o) and “old” (>50 y/o). Results: For the “old” patients (n=15), the median epithelialization percentage at 7 days is 5% and was significantly (P=.023) greater for the experimental dressing. For the “young” patients (n=11), the median epithelialization percentage at 7 days was 80% and there is no significant difference between the experimental and Standard Care control dressings. Conclusions: The experimental dressing significantly increases the rate of epithelialization of acute, traumatic partial-thickness wounds in older patients. We suggest that the dressing may be clinically useful in similar situations where epithelialization may be delayed because of patient or wound characteristics. | en |
dc.format.extent | 375-381 | en |
dc.identifier.eissn | 1937-5719 | en |
dc.identifier.issn | 1937-5719 | en |
dc.identifier.uri | https://hdl.handle.net/10182/8933 | |
dc.language.iso | en | |
dc.publisher | Open Science Co. LLC | |
dc.relation | The original publication is available from - Open Science Co. LLC - http://www.eplasty.com/index.php?option=com_content&view=article&id=1007&catid=186:volume-13-eplasty-2013 | en |
dc.relation.isPartOf | ePlasty | en |
dc.rights | © The Authors | |
dc.subject | acute wounds | en |
dc.subject | donor site | en |
dc.subject | epithelialization | en |
dc.subject | keratin | en |
dc.subject | partial thickness wounds | en |
dc.title | Do functional keratin dressings accelerate epithelialization in human partial thickness wounds? A randomized controlled trial on skin graft donor sites | en |
dc.type | Journal Article | |
lu.contributor.unit | Lincoln University | |
lu.contributor.unit | Lincoln Agritech | |
pubs.notes | E-location ID e45 | en |
pubs.publication-status | Published online | en |
pubs.publisher-url | http://www.eplasty.com/index.php?option=com_content&view=article&id=1007&catid=186:volume-13-eplasty-2013 | en |
pubs.volume | 13 | en |