Quantitative imaging of excised osteoarthritic cartilage using spectral CT
dc.contributor.author | Rajendran, K | |
dc.contributor.author | Löbker, C | |
dc.contributor.author | Schon, BS | |
dc.contributor.author | Bateman, CJ | |
dc.contributor.author | Younis, RA | |
dc.contributor.author | de Ruiter, NJA | |
dc.contributor.author | Chernoglazov, AI | |
dc.contributor.author | Ramyar, M | |
dc.contributor.author | Hooper, GJ | |
dc.contributor.author | Butler, APH | |
dc.contributor.author | Woodfield, TBF | |
dc.contributor.author | Anderson, NG | |
dc.coverage.spatial | Germany | |
dc.date.accessioned | 2017-07-30T23:55:21Z | |
dc.date.available | 2016-05-10 | |
dc.date.issued | 2017-01 | |
dc.date.submitted | 2016-04-18 | |
dc.description.abstract | Objectives To quantify iodine uptake in articular cartilage as a marker of glycosaminoglycan (GAG) content using multi-energy spectral CT. Methods We incubated a 25-mm strip of excised osteoarthritic human tibial plateau in 50 % ionic iodine contrast and imaged it using a small-animal spectral scanner with a cadmium telluride photon-processing detector to quantify the iodine through the thickness of the articular cartilage. We imaged both spectroscopic phantoms and osteoarthritic tibial plateau samples. The iodine distribution as an inverse marker of GAG content was presented in the form of 2D and 3D images after applying a basis material decomposition technique to separate iodine in cartilage from bone. We compared this result with a histological section stained for GAG. Results The iodine in cartilage could be distinguished from subchondral bone and quantified using multi-energy CT. The articular cartilage showed variation in iodine concentration throughout its thickness which appeared to be inversely related to GAG distribution observed in histological sections. Conclusions Multi-energy CT can quantify ionic iodine contrast (as a marker of GAG content) within articular cartilage and distinguish it from bone by exploiting the energy-specific attenuation profiles of the associated materials. Key points • Contrast-enhanced articular cartilage and subchondral bone can be distinguished using multi-energy CT. • Iodine as a marker of glycosaminoglycan content is quantifiable with multi-energy CT. • Multi-energy CT could track alterations in GAG content occurring in osteoarthritis. | |
dc.format.extent | pp.384-392 | |
dc.format.medium | Print-Electronic | |
dc.identifier | 10.1007/s00330-016-4374-7 | |
dc.identifier | https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=elements_prod&SrcAuth=WosAPI&KeyUT=WOS:000389350100043&DestLinkType=FullRecord&DestApp=WOS_CPL | |
dc.identifier.citation | Rajendran et al. (2017). Quantitative imaging of excised osteoarthritic cartilage using spectral CT. European Radiology, 27, 384-392. doi:10.1007/s00330-016-4374-7 | |
dc.identifier.doi | 10.1007/s00330-016-4374-7 | |
dc.identifier.eissn | 1432-1084 | |
dc.identifier.issn | 0938-7994 | |
dc.identifier.other | 27165137 (pubmed) | |
dc.identifier.uri | https://hdl.handle.net/10182/8374 | |
dc.language | en | |
dc.language.iso | en | |
dc.publisher | Springer Verlag on behalf of European Society of Radiology (ESR) | |
dc.relation | The original publication is available from Springer Verlag on behalf of European Society of Radiology (ESR) - https://doi.org/10.1007/s00330-016-4374-7 - http://dx.doi.org/10.1007/s00330-016-4374-7 | |
dc.relation.isPartOf | European Radiology | |
dc.relation.uri | https://doi.org/10.1007/s00330-016-4374-7 | |
dc.rights | © European Society of Radiology | |
dc.subject | osteoarthritis | |
dc.subject | articular cartilage | |
dc.subject | spectral CT | |
dc.subject | glycosaminoglycan | |
dc.subject | ionic contrast media | |
dc.subject.anzsrc | ANZSRC::110320 Radiology and Organ Imaging | |
dc.subject.anzsrc2020 | ANZSRC::3202 Clinical sciences | |
dc.subject.mesh | Cartilage, Articular | |
dc.subject.mesh | Tibia | |
dc.subject.mesh | Humans | |
dc.subject.mesh | Osteoarthritis | |
dc.subject.mesh | Iodine | |
dc.subject.mesh | Glycosaminoglycans | |
dc.subject.mesh | Contrast Media | |
dc.subject.mesh | Tomography, X-Ray Computed | |
dc.subject.mesh | Dissection | |
dc.subject.mesh | Phantoms, Imaging | |
dc.title | Quantitative imaging of excised osteoarthritic cartilage using spectral CT | |
dc.type | Journal Article | |
lu.contributor.unit | LU | |
lu.contributor.unit | LU|Lincoln Agritech | |
lu.contributor.unit | LU|Research Management Office | |
lu.contributor.unit | LU|Research Management Office|OLD QE18 | |
lu.identifier.orcid | 0000-0002-7512-5583 | |
pubs.issue | 1 | |
pubs.publication-status | Published | |
pubs.publisher-url | http://dx.doi.org/10.1007/s00330-016-4374-7 | |
pubs.volume | 27 |