Systems biology of synaptic plasticity: a review on N-methyl-D-aspartate receptor mediated biochemical pathways and related mathematical models
dc.contributor.author | He, Y | |
dc.contributor.author | Kulasiri, Don | |
dc.contributor.author | Samarasinghe, Sandhya | |
dc.coverage.spatial | Ireland | |
dc.date.accessioned | 2017-07-24T04:48:43Z | |
dc.date.available | 2014-06-12 | |
dc.date.issued | 2014-08 | |
dc.date.submitted | 2014-06-06 | |
dc.description.abstract | Synaptic plasticity, an emergent property of synaptic networks, has shown strong correlation to one of the essential functions of the brain, memory formation. Through understanding synaptic plasticity, we hope to discover the modulators and mechanisms that trigger memory formation. In this paper, we first review the well understood modulators and mechanisms underlying N-methyl-D-aspartate receptor dependent synaptic plasticity, a major form of synaptic plasticity in hippocampus, and then comment on the key mathematical modelling approaches available in the literature to understand synaptic plasticity as the integration of the established functionalities of synaptic components. | |
dc.format.extent | pp.7-18 | |
dc.format.medium | Print-Electronic | |
dc.identifier | S0303-2647(14)00086-0 | |
dc.identifier | https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=elements_prod&SrcAuth=WosAPI&KeyUT=WOS:000342531400002&DestLinkType=FullRecord&DestApp=WOS_CPL | |
dc.identifier.citation | He, Y., Kulasiri, D., Samarasinghe, S. (2014). Systems biology of synaptic plasticity: a review on N-methyl-D-aspartate receptor mediated biochemical pathways and related mathematical models. BioSystems, 122, 7-18. doi:10.1016/j.biosystems.2014.06.005 | |
dc.identifier.doi | 10.1016/j.biosystems.2014.06.005 | |
dc.identifier.eissn | 1872-8324 | |
dc.identifier.issn | 0303-2647 | |
dc.identifier.other | 24929130 (pubmed) | |
dc.identifier.uri | https://hdl.handle.net/10182/8350 | |
dc.language | en | |
dc.language.iso | en | |
dc.publisher | Elsevier Ireland | |
dc.relation | The original publication is available from Elsevier Ireland - https://doi.org/10.1016/j.biosystems.2014.06.005 - http://dx.doi.org/10.1016/j.biosystems.2014.06.005 | |
dc.relation.isPartOf | BioSystems | |
dc.relation.uri | https://doi.org/10.1016/j.biosystems.2014.06.005 | |
dc.rights | © 2014 Elsevier Ireland Ltd. All rights reserved. | |
dc.subject | synaptic plasticity | |
dc.subject | systems biology | |
dc.subject | memory formation | |
dc.subject | LTP | |
dc.subject | LTD | |
dc.subject.anzsrc | ANZSRC::0601 Biochemistry and Cell Biology | |
dc.subject.anzsrc | ANZSRC::110199 Medical Biochemistry and Metabolomics not elsewhere classified | |
dc.subject.anzsrc2020 | ANZSRC::31 Biological sciences | |
dc.subject.anzsrc2020 | ANZSRC::40 Engineering | |
dc.subject.mesh | Brain | |
dc.subject.mesh | Humans | |
dc.subject.mesh | Calcium | |
dc.subject.mesh | Calmodulin | |
dc.subject.mesh | Receptors, Glutamate | |
dc.subject.mesh | Receptors, N-Methyl-D-Aspartate | |
dc.subject.mesh | Memory | |
dc.subject.mesh | Systems Biology | |
dc.subject.mesh | Signal Transduction | |
dc.subject.mesh | Neuronal Plasticity | |
dc.subject.mesh | Models, Biological | |
dc.title | Systems biology of synaptic plasticity: a review on N-methyl-D-aspartate receptor mediated biochemical pathways and related mathematical models | |
dc.type | Journal Article | |
lu.contributor.unit | LU | |
lu.contributor.unit | LU|Agriculture and Life Sciences | |
lu.contributor.unit | LU|Agriculture and Life Sciences|WFMB | |
lu.contributor.unit | LU|Faculty of Environment, Society and Design | |
lu.contributor.unit | LU|Faculty of Environment, Society and Design|SOLA | |
lu.contributor.unit | LU|Research Management Office | |
lu.contributor.unit | LU|Research Management Office|OLD QE18 | |
lu.identifier.orcid | 0000-0001-8744-1578 | |
lu.identifier.orcid | 0000-0003-2943-4331 | |
pubs.publication-status | Published | |
pubs.publisher-url | http://dx.doi.org/10.1016/j.biosystems.2014.06.005 | |
pubs.volume | 122 |